| Name | novel protein |
|---|---|
| Synonyms | FAM89A; Novel protein; RP11 423F24.2 |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20064719 | Geldenhuys WJ, Funk MO, Barnes KF, Carroll RT: Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET. Bioorg Med Chem Lett. 2010 Feb 1;20(3):819-23. Epub 2010 Jan 4. To investigate the ability of NL-1 to block rotenone initiated free radicals from complex I, we found it was able to protect the human neuronal cell line SH-SY5Y against rotenone induced cell death. Recently, a search for mitochondrial proteins that bind identified a novel protein, mitoNEET, which was later shown to regulate the oxidative capacity of the mitochondria. |
1(0,0,0,1) | Details |
| 19409963 | Caudle WM, Kitsou E, Li J, Bradner J, Zhang J: A role for a novel protein, nucleolin, in Parkinson's disease. Neurosci Lett. 2009 Jul 31;459(1):11-5. Epub 2009 May 4. Furthermore, manipulation of nucleolin in an in vitro model of PD resulted in significant alterations in the generation of oxidative stress as well as proteasomal inhibition following rotenone exposure. |
1(0,0,0,1) | Details |
| 18638544 | Rathore R, Zheng YM, Niu CF, Liu QH, Korde A, Ho YS, Wang YX: Hypoxia activates oxidase to increase [ROS] i and [Ca2+] i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells. Free Radic Biol Med. 2008 Nov 1;45(9):1223-31. Epub 2008 Jun 21. Inhibition of mitochondrial ROS generation with rotenone or myxothiazol prevented hypoxic activation of Nox. |
0(0,0,0,0) | Details |