| Name | NF kappa B |
|---|---|
| Synonyms | DNA binding factor KBF1; EBP 1; KBF 1; KBF1; NF kappa B; NFKB p105; NFKB p50; NFKB 1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9655528 | Josse C, Legrand-Poels S, Piret B, Sluse F, Piette J: Impairment of the mitochondrial electron chain transport prevents NF-kappa B activation by peroxide. Free Radic Biol Med. 1998 Jul 1;25(1):104-12. In this report, we first demonstrated that inhibition of the electron transport chain by either rotenone or antimycine A gave rise to dose-dependent inhibition of NF-kappa B translocation induced by 150 microM of peroxide (H2O2). |
85(1,1,1,5) | Details |
| 7963561 | Suzuki YJ, Mizuno M, Packer L: Signal transduction for nuclear factor-kappa B activation. J Immunol. 1994 Dec 1;153(11):5008-15. The mitochondrial inhibitor, rotenone, also inhibited NF-kappa B activation by calyculin A; however, this inhibition was accompanied by a depletion of cellular ATP. |
82(1,1,1,2) | Details |
| 15256069 | Ebadi M, Sharma SK, Wanpen S, Amornpan A: inhibits mitochondrial complex-1 down-regulation and nuclear factor-kappa B activation. J Cell Mol Med. 2004 Apr-Jun;8(2):213-22. Rotenone inhibited complex-1, enhanced nuclear factor-kappa B, and caused apoptosis in human dopaminergic (SK-N-SH) neurons; whereas nuclear factor-kappa B antibody suppressed rotenone-induced apoptosis, suggesting that enhancing (10) synthesis and suppressing the induction of NF-kappa B, may provide neuroprotection. |
81(1,1,1,1) | Details |
| 8882611 | Kengatharan M, De Kimpe SJ, Thiemermann C: Analysis of the signal transduction in the induction of synthase by lipoteichoic acid in macrophages. Br J Pharmacol. 1996 Mar;117(6):1163-70. Inhibitors of the activation of the nuclear transcription factor NF-kappa B such as pyrrolidine dithiocarbamate (PDTC; an antioxidant and a metal chelator), butylated hydroxyanisole (BHA; an antioxidant), L-1-tosylamido-2-phenylethyl chloromethyl ketone (TPCK), calpain inhibitor I (both I kappa B-protease inhibitors), or rotenone (an antioxidant which inhibits electron transport) prevented the nitrite formation stimulated by LTA. |
32(0,1,1,2) | Details |
| 8875956 | Corsini E, Schubert C, Marinovich M, Galli CL: Role of mitochondria in tributyltin-induced interleukin-1alpha production in murine keratinocytes. J Invest Dermatol. 1996 Nov;107(5):720-5. At different times thereafter (0--24 h), nuclear extracts were analyzed for nuclear factor-(kappa) B (NF-(kappa) B) binding activity by electrophoretic mobility shift assay, and the released and cell-associated IL-1alpha was measured by enzyme-linked immunosorbent assay. TBT induced a direct and concentration-related activation of NF-(kappa) B, which peaked at 2 h and was blocked by pyrrolidinedithiocarbamate, a potent NF-(kappa) B inhibitor, and rotenone, an inhibitor of the electron entry from complex I to |
2(0,0,0,2) | Details |
| 10878378 | Chandel NS, Trzyna WC, McClintock DS, Schumacker PT: Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. J Immunol. 2000 Jul 15;165(2):1013-21. Rotenone, an inhibitor of mitochondrial complex I, abolished the increase in ROS signal, the activation of NF-kappa B, and TNF-alpha gene transcription during hypoxia. |
7(0,0,0,7) | Details |
| 7476912 | Garcia-Ruiz C, Colell A, Morales A, Kaplowitz N, Fernandez-Checa JC: Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes. Mol Pharmacol. 1995 Nov;48(5):825-34. In addition, with electrophoretic mobility shift assay of the transcription factor nuclear factor-kappa B (NF-kappa B), we detected its activation in response to AA (2-3-fold). However, blockade of complex I or II with rotenone or thenoyltrifluoroacetone, respectively, did not result in accumulation of peroxide. |
3(0,0,0,3) | Details |
| 8760145 | Warner BB, Stuart L, Gebb S, Wispe JR: Redox regulation of manganese superoxide dismutase. . Am J Physiol. 1996 Jul;271(1 Pt 1):L150-8. DNA binding of two redox-sensitive transcription factors, NF-kappa B and activator protein (AP)-1, was evaluated. |
1(0,0,0,1) | Details |
| 12208513 | Wu HM, Chi KH, Lin WW: Proteasome inhibitors stimulate activator protein-1 pathway via reactive species production. FEBS Lett. 2002 Aug 28;526(1-3):101-5. The stimulating effects on IL-8 promoter and AP-1 were reduced by diphenyleneiodonium, rotenone and antimycin A. These results suggest that ROS production by proteasome inhibitors leads to AP-1 activation, which in the absence of NF-kappa B activation still transactivates IL-8 gene expression. |
1(0,0,0,1) | Details |