| Name | p67 phox |
|---|---|
| Synonyms | 67 kDa neutrophil oxidase factor; NCF 2; NCF2; NOXA 2; NOXA2; Neutrophil NADPH oxidase factor 2; Neutrophil cytosol factor 2; Neutrophil cytosolic factor 2… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19371610 | Mo Y, Wan R, Chien S, Tollerud DJ, Zhang Q: Activation of endothelial cells after exposure to ambient ultrafine particles: the role of oxidase. Toxicol Appl Pharmacol. 2009 Apr 15;236(2):183-93. Epub 2009 Feb 5. Our results showed that UFPs, at a non-toxic dose, induced reactive species (ROS) generation in mouse pulmonary microvascular endothelial cells (MPMVEC) that was inhibited by pre-treatment with the ROS scavengers or inhibitors, but not with the mitochondrial inhibitor, rotenone. Moreover, Western blot and immunofluorescence staining results showed that MPMVEC treated with UFPs resulted in the translocation of cytosolic proteins of oxidase, p47 (phox), p67 (phox) and rac 1, to the plasma membrane. |
2(0,0,0,2) | Details |
| 19781192 | Chen Y, Zhang AH, Huang SM, Ding GX, Zhang WZ, Bao HY, Wu HM, Chen RH: oxidase-derived reactive species involved in angiotensin II-induced monocyte chemoattractant protein-1 expression in mesangial cells]. Zhonghua Bing Li Xue Za Zhi. 2009 Jul;38(7):456-61. In contrast, inhibitors of other oxidant-producing enzymes, including the mitochondrial complex Iinhibitor rotenone, the xanthine oxidase inhibitor allopurinol, the cyclooxygenase inhibitor indomethacin, the lipoxygenase inhibitor nordihydroguiaretic acid, the cytochrome P450 oxygenase inhibitor ketoconazole and the synthase inhibitor G-nitro- methyl ester were without an effect. oxidase activity was examined by lucigenin chemiluminescence. p47phox and p67phox translocation was assayed by Western blot. |
2(0,0,0,2) | Details |
| 12388366 | Parinandi NL, Kleinberg MA, Usatyuk PV, Cummings RJ, Pennathur A, Cardounel AJ, Zweier JL, Garcia JG, Natarajan V: Hyperoxia-induced NAD (P) H oxidase activation and regulation by MAP kinases in human lung endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2003 Jan;284(1):L26-38. Epub 2002 Jul 26. Exposure of HPAECs to hyperoxia for 1, 3, and 12 h increased the generation of which was blocked by diphenyleneiodonium but not by rotenone or Immunohistocytochemistry and Western blotting revealed the presence of gp91, p67 phox, p22 phox, and p47 phox subcomponents of oxidase in HPAECs. |
1(0,0,0,1) | Details |
| 9886268 | Sambo P, Jannino L, Candela M, Salvi A, Donini M, Dusi S, Luchetti MM, Gabrielli A: Monocytes of patients wiht systemic sclerosis (scleroderma spontaneously release in vitro increased amounts of J Invest Dermatol. 1999 Jan;112(1):78-84. The involvement of oxidase in the enhanced 02*- production was demonstrated by the finding that the cytosolic components of the enzyme, p47phox and p67phox, were both translocated to the plasma membrane of enriched but otherwise unmanipulated monocytes of SSc patients. The involvement of mitochondrial oxidases was excluded by the lack of inhibition of O2*- production when monocytes were incubated in the presence of rotenone, a mitochondrial oxidase inhibitor. |
1(0,0,0,1) | Details |
| 16207877 | Abramov AY, Jacobson J, Wientjes F, Hothersall J, Canevari L, Duchen MR: Expression and modulation of an oxidase in mammalian astrocytes. . J Neurosci. 2005 Oct 5;25(40):9176-84. This was independent of mitochondrial ROS production, because it was unaffected by mitochondrial depolarization with rotenone and oligomycin. Expression of gp91phox and p67phox was increased in reactive astrocytes, which showed increased rates of both resting and stimulated ROS generation. |
1(0,0,0,1) | Details |
| 17881465 | Ding G, Zhang A, Huang S, Pan X, Zhen G, Chen R, Yang T: ANG II induces c-Jun NH2-terminal kinase activation and proliferation of human mesangial cells via redox-sensitive transactivation of the EGFR. Am J Physiol Renal Physiol. 2007 Dec;293(6):F1889-97. Epub 2007 Sep 19. In contrast, inhibitors of other oxidant-producing enzymes, including the mitochondrial complex I inhibitor rotenone, the xanthine oxidase inhibitor allopurinol, the cyclooxygenase inhibitor indomethacin, the lipoxygenase inhibitor nordihydroguiaretic acid, the cytochrome P-450 oxygenase inhibitor ketoconazole, and the synthase inhibitor N (G)-nitro- methyl ester, were without effect. ANG II induced translocation of p47 (phox) and p67 (phox) from the cytosol to the membrane. |
1(0,0,0,1) | Details |
| 12615666 | Ungvari Z, Csiszar A, Edwards JG, Kaminski PM, Wolin MS, Kaley G, Koller A: Increased production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD (P) H oxidase, and inducible synthase. Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):418-24. Epub 2003 Feb 13. METHODS AND RESULTS: The increased generation of O2*- by HHcy coronary arteries was inhibited by SOD, diphenyleneiodonium, apocynin, and apocynin plus amino but was unaffected by allopurinol and rotenone. Expression of p67phox, p22phox, and p47phox subunits and that of endothelial nitric oxide synthase, Cu,Zn-SOD, Mn-SOD, extracellular SOD (mRNA), and xanthine oxidase was unchanged. |
1(0,0,0,1) | Details |
| 18638544 | Rathore R, Zheng YM, Niu CF, Liu QH, Korde A, Ho YS, Wang YX: Hypoxia activates oxidase to increase [ROS] i and [Ca2+] i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells. Free Radic Biol Med. 2008 Nov 1;45(9):1223-31. Epub 2008 Jun 21. In this study, using Western blot analysis we found that the major Nox subunits Nox1, Nox4, p22 (phox), p47 (phox), and p67 (phox) were equivalently expressed in mouse pulmonary and systemic (mesenteric) arteries. Inhibition of mitochondrial ROS generation with rotenone or myxothiazol prevented hypoxic activation of Nox. |
1(0,0,0,1) | Details |
| 16762927 | Hidalgo C, Sanchez G, Barrientos G, Aracena-Parks P: A transverse tubule oxidase activity stimulates release from isolated triads via ryanodine receptor type 1 S -glutathionylation. J Biol Chem. 2006 Sep 8;281(36):26473-82. Epub 2006 Jun 8. or elicited and peroxide generation by isolated triads; both activities were inhibited by NOX inhibitors but not by rotenone. |
0(0,0,0,0) | Details |