| Name | hypoxia inducible factor 1alpha |
|---|---|
| Synonyms | ARNT interacting protein; HIF 1 alpha; HIF 1alpha; HIF1 alpha; HIF1A; Hypoxia inducible factor 1 alpha subunit; Hypoxia inducible factor 1 alpha; Hypoxia inducible factor 1alpha… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12376345 | Schroedl C, McClintock DS, Budinger GR, Chandel NS: Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive species. Am J Physiol Lung Cell Mol Physiol. 2002 Nov;283(5):L922-31. The molecular mechanisms by which cells detect hypoxia (1.5% O2), resulting in the stabilization of hypoxia-inducible factor 1alpha (HIF-1alpha) protein remain unclear. Primary evidence for this model comes from the observation that cells treated with complex I inhibitors, such as rotenone, or cells that lack mitochondrial DNA (rho (0)-cells) fail to generate reactive species or stabilize HIF-1alpha protein in response to hypoxia. |
1(0,0,0,1) | Details |
| 19196431 | Guglielmotto M, Aragno M, Autelli R, Giliberto L, Novo E, Colombatto S, Danni O, Parola M, Smith MA, Perry G, Tamagno E, Tabaton M: The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha. J Neurochem. 2009 Feb;108(4):1045-56. Specifically, hypoxia significantly increases beta-site APP cleaving enzyme (BACE1) gene transcription through the over-expression of hypoxia inducible factor 1alpha, resulting in increased BACE1 secretase activity and amyloid-beta production. The involvement of reactive species released by mitochondria in the BACE1 up-regulation was confirmed by the complete protection exerted by complex I inhibitors such as rotenone and diphenyl-phenylen iodonium. |
2(0,0,0,2) | Details |
| 12062197 | Agani FH, Pichiule P, Carlos Chavez J, LaManna JC: Inhibitors of mitochondrial complex I attenuate the accumulation of hypoxia-inducible factor-1 during hypoxia in Hep3B cells. Comp Biochem Physiol A Mol Integr Physiol. 2002 May;132(1):107-9. Because mitochondria have been postulated to be involved in the regulation of HIF-1, we tested the effects of mitochondrial electron transport chain complex I inhibitors, rotenone and 1-methyl-4-phenylpiridinium (MPP (+)), on hypoxic-induced accumulation of HIF-1 alpha, the regulated component of the dimer. |
38(0,1,2,3) | Details |
| 16034640 | Baby SM, Roy A, Lahiri S: Role of mitochondria in the regulation of hypoxia-inducible factor-1alpha in the rat carotid body glomus cells. Histochem Cell Biol. 2005 Jul;124(1):69-76. Epub 2005 Jul 22. To test this hypothesis in the CB glomus cells, we studied the effect of mitochondrial electron transport chain (ETC) inhibitors: rotenone (complex I; 1 microM), (complex II; 0.5 M), antimycin A (complex III; 1 microg/ml), azide (complex IV; 5 mM), and uncoupler of oxidative phosphorylation: carbonyl p-trifluoromethoxyphenylhydrazone (FCCP; 1 mM) on HIF-1alpha expression during normoxia and hypoxia. |
2(0,0,0,2) | Details |
| 11504687 | Andrew AS, Klei LR, Barchowsky A: requires hypoxia-inducible factor-1 alpha, not redox signaling, to induce plasminogen activator inhibitor-1. Am J Physiol Lung Cell Mol Physiol. 2001 Sep;281(3):L607-15. Because is known to mimic hypoxia, the present study examined whether transcriptionally activates PAI-1 through the hypoxia-inducible factor (HIF)-1 alpha signaling pathway. |
1(0,0,0,1) | Details |
| 19139008 | Kim WY, Chang DJ, Hennessy B, Kang HJ, Yoo J, Han SH, Kim YS, Park HJ, Seo SY, Mills G, Kim KW, Hong WK, Suh YG, Lee HY: A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy. Cancer Prev Res (Phila Pa). 2008 Dec;1(7):577-87. Four derivatives destabilized hypoxia-inducible factor-1alpha as potently as did deguelin. |
1(0,0,0,1) | Details |
| 18575727 | Lee JH, Lee DH, Lee HS, Choi JS, Kim KW, Hong SS: Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis. Oncol Rep. 2008 Jul;20(1):129-34. Treatment of HepG2 cells with deguelin for 16 h under hypoxia conditions reduced the expression of the hypoxia-inducible factor 1alpha protein and vascular endothelial growth factor mRNA in a dose-dependent manner. |
1(0,0,0,1) | Details |
| 17764071 | Oh SH, Woo JK, Jin Q, Kang HJ, Jeong JW, Kim KW, Hong WK, Lee HY: Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha. Int J Cancer. 2008 Jan 1;122(1):5-14. |
1(0,0,0,1) | Details |
| 16344601 | French SW: The pathogenesis and significance of the urinary cycle in rats fed intragastrically. Alcohol Clin Exp Res. 2005 Nov;29(11 Suppl):158S-161S. When complex I (NADH dehydrogenase) of the mitochondrial electron transport chain is inhibited by feeding rotenone, the cycle is totally eliminated and blood levels remain constant at 200 mg/%. The genes responsive to hypoxia inducible factor 1alpha (HIF1alpha) regulation are increased including the expression of erythropoietin, adrenomedullin and adrenergic receptor alpha 1a and d. |
1(0,0,0,1) | Details |
| 17565155 | Oh SH, Woo JK, Yazici YD, Myers JN, Kim WY, Jin Q, Hong SS, Park HJ, Suh YG, Kim KW, Hong WK, Lee HY: Structural basis for depletion of heat shock protein 90 client proteins by deguelin. J Natl Cancer Inst. 2007 Jun 20;99(12):949-61. Epub 2007 Jun 12. BACKGROUND: The molecular chaperone heat shock protein 90 (Hsp90) participates in preserving the expression and activity of various oncoproteins, including hypoxia-inducible factor 1alpha (HIF-1alpha) and Akt. |
1(0,0,0,1) | Details |