Protein Information

Name Mnk 1
Synonyms MAP kinase interacting serine/threonine kinase 1; MAP kinase signal integrating kinase 1; MAP kinase interacting serine/threonine protein kinase 1; MKNK 1; MKNK1; MNK 1; MNK1; MAP kinase signal integrating kinase 1s…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
17707924 Perez de Obanos MP, Lopez-Zabalza MJ, Arriazu E, Modol T, Prieto J, Herraiz MT, Iraburu MJ: Reactive oxygen species (ROS) mediate the effects of leucine on translation regulation and type I collagen production in hepatic stellate cells. Biochim Biophys Acta. 2007 Nov;1773(11):1681-8. Epub 2007 Jul 24.

Preincubation with glutathione also prevented 4E-BP1, eIF4E and Mnk-1 phosphorylation induced by leucine, as well as enhancement of procollagen alpha1 (I) protein levels.
The mitochondrial electron chain inhibitor rotenone and the NADPH oxidase inhibitor apocynin prevented reactive oxygen species production caused by leucine.		 1(0,0,0,1) Details