| Name | glutathione peroxidase 1 |
|---|---|
| Synonyms | Cellular glutathione peroxidase; GPX1; GPx 1; GSHPX1; GSHPx 1; Glutathione peroxidase 1; GPx 1s; GSHPx 1s… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17291988 | Wang QS, Zheng YM, Dong L, Ho YS, Guo Z, Wang YX: Role of mitochondrial reactive species in hypoxia-dependent increase in intracellular in pulmonary artery myocytes. Free Radic Biol Med. 2007 Mar 1;42(5):642-53. Epub 2006 Dec 14. Glutathione peroxidase-1 (Gpx1) or catalase gene overexpression to enhance H2O2 removal remarkably reduced hypoxic increases in [ROS] i and [Ca2+] i, whereas Gpx1 gene deletion had the opposite effect. Moreover, H2O2 (5.1 microM) reversed the inhibition of the hypoxia-induced increase in [Ca2+] i by rotenone. |
1(0,0,0,1) | Details |
| 17657281 | Panee J, Liu W, Nakamura K, Berry MJ: The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of supplementation. Int J Biol Sci. 2007 Jul 13;3(5):335-41. Unexpectedly, the expression of the enzymes that directly scavenge ROS decreased, including superoxide dismutases 1 and 2, glutathione peroxidase 1, and catalase. |
1(0,0,0,1) | Details |
| 18638544 | Rathore R, Zheng YM, Niu CF, Liu QH, Korde A, Ho YS, Wang YX: Hypoxia activates oxidase to increase [ROS] i and [Ca2+] i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells. Free Radic Biol Med. 2008 Nov 1;45(9):1223-31. Epub 2008 Jun 21. Inhibition of mitochondrial ROS generation with rotenone or myxothiazol prevented hypoxic activation of Nox. Glutathione peroxidase-1 (Gpx1) gene overexpression to enhance H (2) O (2) removal significantly inhibited the hypoxic activation of Nox, whereas Gpx1 gene deletion had the opposite effect. |
1(0,0,0,1) | Details |
| 20227863 | He M, Siow RC, Sugden D, Gao L, Cheng X, Mann GE: Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: A role for Nrf2 in vascular protection in diabetes. Nutr Metab Cardiovasc Dis. 2010 Mar 12. Inhibition of ROS production with the scavenger Tiron or inhibitors of flavoproteins (diphenylene iodonium) and oxidase (apocynin), but not eNOS (l-NAME) or mitochondria complex I (rotenone) abrogated HO-1 induction by AGE-BSA. |
0(0,0,0,0) | Details |
| 17087917 | Rathore R, Zheng YM, Li XQ, Wang QS, Liu QH, Ginnan R, Singer HA, Ho YS, Wang YX: Mitochondrial ROS-PKCepsilon signaling axis is uniquely involved in hypoxic increase in [Ca2+] i in pulmonary artery smooth muscle cells. Biochem Biophys Res Commun. 2006 Dec 22;351(3):784-90. Epub 2006 Oct 30. Inhibition of mitochondrial ROS generation with rotenone, myxothiazol, or glutathione peroxidase-1 overexpression prevented hypoxia-induced increases in total PKC and PKCepsilon activity in pulmonary arteries. |
81(1,1,1,1) | Details |