| Name | malate dehydrogenase |
|---|---|
| Synonyms | ME3; Malate dehydrogenase; NADP ME; Pyruvic malic carboxylase; Malic enzyme 3; Mitochondrial NADP(+) dependent malic enzyme 3; Malic enzyme 3s; Mitochondrial NADP(+) dependent malic enzyme 3s |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16661455 | Rustin P, Moreau F, Lance C: Oxidation in Plant Mitochondria via Malic Enzyme and the -insensitive Electron Transport Pathway. Plant Physiol. 1980 Sep;66(3):457-462. In cauliflower, mitochondria oxidation via malate dehydrogenase is rotenone- and -sensitive. |
89(1,1,2,4) | Details |
| 16662080 | Johnson-Flanagan AM, Spencer MS: The Effect of Rotenone on Respiration in Pea Cotyledon Mitochondria. . Plant Physiol. 1981 Dec;68(6):1211-1217. Rotenone also inhibited the NADH dehydrogenase associated with malate dehydrogenase. |
82(1,1,1,2) | Details |
| 6460022 | Schwitzguebel JP, Palmer JM: Properties of mitochondria as a function of the growth stages of Neurospora crassa. J Bacteriol. 1982 Feb;149(2):612-9. With (plus as a substrate, the sensitivity to rotenone and the ADP/O ratios were always lower than those observed with other NAD-linked substrates, suggesting a possible cooperation between malate dehydrogenase and the rotenone-resistant pathway. |
81(1,1,1,1) | Details |
| 3037203 | Massie HR, Kogut KA: Influence of age on mitochondrial enzyme levels in Drosophila. Mech Ageing Dev. 1987 Apr;38(2):119-26. The enzymes assayed were rotenone-insensitive -cytochrome c reductase, kinase, cytochrome c reductase, and malate dehydrogenase, located in the outer membrane, inner membrane space, inner membrane and matrix, respectively. |
81(1,1,1,1) | Details |
| 6625611 | Walker GH, Oliver DJ: Changes in the electron transport chain of pea leaf mitochondria metabolizing Arch Biochem Biophys. 1983 Sep;225(2):847-53. At higher concentrations the rotenone-insensitive NADH dehydrogenase was increasingly important and its increased electron transport capacity was best exploited by malate dehydrogenase. |
81(1,1,1,1) | Details |
| 16663348 | Chauveau M, Dizengremel P, Roussaux J: Interaction of Benzylaminopurine with Electron Transport in Plant Mitochondria during Oxidation. Plant Physiol. 1983 Dec;73(4):945-948. A pH of 7.7 favored the activity of malate dehydrogenase, which is connected with a rotenone-sensitive NADH dehydrogenase, whereas at pH 6.5 malic enzyme, linked to a rotenone-resistant NADH dehydrogenase, was more active.Experimental results indicate the existence of two sites of inhibition for BA. |
31(0,1,1,1) | Details |
| 19495970 | Villa RF, Gorini A, Hoyer S: Effect of Ageing and Ischemia on Enzymatic Activities Linked to Krebs' Cycle, Electron Transfer Chain, and Aminoacids Metabolism of Free and Intrasynaptic Mitochondria of Cerebral Cortex. Neurochem Res. 2009 Jun 4. The maximum rate (V (max)) of the following enzyme activities: citrate synthase, malate dehydrogenase, succinate dehydrogenase for Krebs' cycle; -cytochrome c reductase as total (integrated activity of Complex I-III), rotenone sensitive (Complex I) and cytochrome oxidase (Complex IV) for electron transfer chain; dehydrogenase, -- and glutamate-pyruvate transaminases for glutamate metabolism were assayed in non-synaptic, perikaryal mitochondria and in two populations of intra-synaptic mitochondria, i.e., the light and heavy mitochondrial fraction. |
31(0,1,1,1) | Details |
| 17551845 | Ivanov B, Asada K, Edwards GE: Analysis of donors of electrons to photosystem I and cyclic electron flow by redox kinetics of P700 in chloroplasts of isolated bundle sheath strands of maize. Photosynth Res. 2007 Apr;92(1):65-74. Epub 2007 Jun 6. Bundle sheath chloroplasts of -malic enzyme (NADP-ME) type C4 species have a high demand for ATP, while being deficient in linear electron flow and oxidation of water by photosystem II (PSII). The inhibitors of dehydrogenase (NDH), amytal and rotenone, accelerated the oxidation rate of P700 by far-red light after AL, indicating donation of electrons to the intersystem from stromal donors via NDH. |
3(0,0,0,3) | Details |
| 22598 | Della Corte L, Callingham BA: The influence of adrenalectomy on monoamine oxidase and cytochrome c reductase in the rat heart. J Pharm Pharmacol. 1977 Nov;29(11):657-63. The effect of adrenalectomy on the activities of monoamine oxidase (MAO), cytochrome c reductase (NCR), succinate dehydrogenase, malate dehydrogenase, fumarase, NAD+ nucleosidase and acid phosphatase in homogenates of rat hearts was examined. However, both the total and the rotenone-insensitive NCR activities increased, with that of the rotenone-insensitive being about half of the total, which indicated that the effect of adrenalectomy was exerted on components of this enzyme localized on both the inner and outer membranes of the mitochondrion. |
1(0,0,0,1) | Details |
| 10844979 | Obungu VH, Kiaira JK, Olembo NK, Njogu MR: Pathways of catabolism in procyclic Trypanosoma congolense. Indian J Biochem Biophys. 1999 Oct;36(5):305-11. Studies of respiration on in procyclic Trypanosoma congolense in the presence of rotenone, antimycin, salicylhydroxamic acid and have indicated the presence of NADH dehydrogenase, cytochrome b-c1, cytochrome aa3, trypanosome alternate oxidase and reductase/succinate dehydrogenase pathway that contributes electrons to of the respiratory chain. Phosphoenolpyruvate carboxykinase, pyruvate dehydrogenase, succinate dehydrogenase, (+)-linked malic enzyme, reductase, malate dehydrogenase, and alpha-ketoglutarate dehydrogenase and glycerol kinase on the other hand had specific activities greater than 60 nanomoles/min/mg protein. |
1(0,0,0,1) | Details |
| 6088521 | Erecinska M, Wilson DF: Relationship of the intra- and extramitochondrial nucleotide ratios during synthesis of using extramitochondrial ATP. J Biol Chem. 1984 Sep 10;259(17):10904-6. Chem. 258, 10464-10473) that phosphoenolpyruvate carboxykinase is freely reversible and that, in conjunction with nucleoside diphosphate kinase and malate dehydrogenase, which are also present in the mitochondria, it can be used to measure the intramitochondrial [ATPfree]/[ADPfree]. In this study, synthesis of by guinea pig liver mitochondria was studied under conditions for which the only source of GTP was extramitochondrial ATP via nucleotide translocase and nucleoside diphosphate kinase (the mitochondria were treated with rotenone, oligomycin, uncoupler, and fluorocitrate). |
1(0,0,0,1) | Details |
| 10425713 | Obungu VH, Kiaira JK, Njogu RM, Olembo NK: Catabolism of by procyclic culture forms of Trypanosoma congolense. Comp Biochem Physiol B Biochem Mol Biol. 1999 May;123(1):59-65. Rotenone had no effect on the rate of respiration except when the intact cells were first permeabilized by digitonin after which rotenone decreased the rate of respiration by 20-30%. Enzymes involved in the catabolism of with high activities were: proline dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, fumarase, -linked malic enzyme, alanine aminotransferase and malate dehydrogenase. |
1(0,0,0,1) | Details |
| 7077455 | Fioravanti CF: Mitochondrial malate dehydrogenase, decarboxylating ("malic" enzyme) and transhydrogenase activities of adult Hymenolepis microstoma (Cestoda). J Parasitol. 1982 Apr;68(2):213-20. The electron transport system of this cestode was apparently specific for both in terms of the rotenone-sensitive oxidase and reductase systems. |
2(0,0,0,2) | Details |
| 2001241 | Rustin P, Lance C: -driven reverse electron transport in the respiratory chain of plant mitochondria. Biochem J. 1991 Feb 15;274 ( Pt 1):249-55. The effects of rotenone and adenylates in relation to and metabolism.. Depending on the experimental conditions, malic enzyme (at pH 6.6 or in the presence of added or malate dehydrogenase (at pH 7.9) were involved in this oxidation. |
2(0,0,0,2) | Details |
| 753379 | Comte J, Gautheron DC: The markers of pig heart mitochondrial sub-fractions. Biochimie. 1978;60(11-12):1298-1305. II. - On the association of malate dehydrogenase with inner membrane.. High ionic strength treatments by either NaCl- or 3M KCl have a strong effect, but they also remove cytochrome c oxidase and rotenone-sensitive -cytochrome c reductase, reputed inner membrane intrinsic enzymes, thus strongly damaging the inner membrane. |
2(0,0,0,2) | Details |
| 16662684 | Moreau F, Romani R: Oxidation and -Insensitive Respiration in Avocado Mitochondria during the Climacteric Cycle. Plant Physiol. 1982 Nov;70(5):1385-1390. The capacity for -insensitive respiration is also considerably enhanced while respiratory control decreases (from 3.3 to 1.7), leading to high state 4 rates.Both malate dehydrogenase and malic enzyme are functional in state 3, but malic enzyme appears to predominate before the addition of ADP and after its depletion. -insensitive oxidation can be either coupled to the first phosphorylation site, sensitive to rotenone, or by-pass this site. |
2(0,0,0,2) | Details |
| 18403382 | Hong HT, Nose A, Agarie S, Yoshida T: metabolism in Hoya carnosa mitochondria and its role in photosynthesis during CAM phase III. J Exp Bot. 2008;59(7):1819-27. Epub 2008 Apr 9. The mitochondria showed high malate dehydrogenase (mMDH) and amino transferase (mAST), and a significant amount of malic enzyme (mME) activities. |
1(0,0,0,1) | Details |
| 16663322 | Day DA, Neuburger M, Douce R, Wiskich JT: Exogenous NAD Effects on Plant Mitochondria: A Reinvestigation of the Transhydrogenase Hypothesis. Plant Physiol. 1983 Dec;73(4):1024-1027. Addition of NAD (+) to purified potato (Solanum tuberosum L.) mitochondria respiring alpha-ketoglutarate and in the presence of the electron transport inhibitor rotenone, stimulated O (2) uptake. The extent of external NAD (+) reduction was correlated with the amount of extra mitochondrial malate dehydrogenase present. |
1(0,0,0,1) | Details |
| 15032834 | Hagedorn PH, Flyvbjerg H, Moller IM: Modelling turnover in plant mitochondria. . Physiol Plant. 2004 Mar;120(3):370-385. It is produced by enzymes in, or associated with, the tricarboxylic acid cycle in the matrix, and it is oxidized by two respiratory chain enzymes in the inner membrane, the rotenone-sensitive complex I and the rotenone-insensitive internal NADH dehydrogenase (ND (in)). Only the two main -producing enzymes, NAD-malate dehydrogenase [EC 1.1.1.37] (MDH) and NAD-malic enzyme [EC 1.1.1.39] (ME), are considered. |
1(0,0,0,1) | Details |
| 12950736 | Dell'Anna ML, Urbanelli S, Mastrofrancesco A, Camera E, Iacovelli P, Leone G, Manini P, D'Ischia M, Picardo M: Alterations of mitochondria in peripheral blood mononuclear cells of vitiligo patients. Pigment Cell Res. 2003 Oct;16(5):553-9. Moreover, a marked increase in the expression of mitochondrial malate dehydrogenase activity and a specific sensitivity to electron transport chain complex I inhibitor were observed. |
1(0,0,0,1) | Details |
| 16416317 | Igamberdiev AU, Shen T, Gardestrom P: Function of mitochondria during the transition of barley protoplasts from low light to high light. Planta. 2006 Jun;224(1):196-204. Epub 2006 Jan 17. Rapid fractionation of protoplasts was used to follow changes in sub-cellular distribution of key metabolites during the light shift and the activation state of chloroplastic -dependent malate dehydrogenase (EC 1.1.1.82) was measured. Rotenone (an inhibitor of mitochondrial complex I) had similar, but less pronounced effect as oligomycin. |
1(0,0,0,1) | Details |
| 1734891 | Atlante A, Passarella S, Quagliariello E: / antiporter in rat liver mitochondria. . Biochem Biophys Res Commun. 1992 Jan 31;182(2):931-8. To gain some insight into the process by which both acetylCoA and needed for fatty acid synthesis, are obtained, in the cytosol, from the effluxed intramitochondrial via citrate lyase and malate dehydrogenase plus malic enzyme respectively, the capability of externally added to cause efflux of from rat liver mitochondria was tested. |
1(0,0,0,1) | Details |
| 1634944 | Carvalho PA, Chiu ML, Kronauge JF, Kawamura M, Jones AG, Holman BL, Piwnica-Worms D: Subcellular distribution and analysis of technetium-99m-MIBI in isolated perfused rat hearts. J Nucl Med. 1992 Aug;33(8):1516-22. To address the apparent discrepancy between cultured cells and whole heart preparations, Langendorff-perfused rat hearts loaded with hexakis (2-methoxyisobutyl isonitrile) technetium (I) (99mTc-MIBI) were fractionated by a standard differential centrifugation method and fractional contents of 99mTc-MIBI were correlated with the mitochondrial marker, malate dehydrogenase (MDH), and mitochondrial substrates. Addition of the mitochondrial uncoupler CCCP (5 microM) to both "mitochondrial" and "cell fragment" pellets released up to 84% +/- 8% of 99mTc-MIBI content and addition of the mitochondrial substrate (10 microM) in the presence of rotenone (1 microM) enhanced 99mTc-MIBI content by up to 139% +/- 52% over the control. |
1(0,0,0,1) | Details |
| 6819864 | Palmer JM, Schwitzguebel JP, Moller IM: Regulation of oxidation in plant mitochondria. Biochem J. 1982 Dec 15;208(3):703-11. Exogenous NAD+ stimulated the rotenone-resistant oxidation of all the NAD+-linked tricarboxylic acid-cycle substrates in mitochondria from Jerusalem artichoke (Helianthus tuberosus L.) tubers. Added NAD+ stimulated the activity of malic enzyme and displaced the equilibrium of malate dehydrogenase; both observations are consistent with entry of NAD+ into the matrix space. |
1(0,0,0,1) | Details |
| 19670830 | Mali Y, Zisapel N: A novel decoy that interrupts G93A-superoxide dismutase gain of interaction with malate dehydrogenase improves survival in an amyotrophic lateral sclerosis cell model. J Med Chem. 2009 Sep 10;52(17):5442-8. A cell permeable 5-carboxytetramethylrhodamine derivative of the decoy peptide improved ATP content of motor neuron derived NSC-34 cells expressing G93AhSOD1 and enhanced cell survival under rotenone and low challenges. |
1(0,0,0,1) | Details |
| 1176438 | Hillar M, Lott V, Lennox B: Correlation of the effects of cycle metabolites on oxidation by rat liver mitochondria and submitochondrial particles. J Bioenerg. 1975 Mar;7(1):1-16. Stimulation by alpha-ketoglutarate and is not influenced by the presence of rotenone. 4. supplies in mitochondria reducing equivalents for malate dehydrogenase operating in the reverse direction-reduction of to 5. |
1(0,0,0,1) | Details |
| 4005310 | Sanchez-Jimenez F, Martinez P, Nunez de Castro I, Olavarria JS: The function of redox shuttles during aerobic glycolysis in two strains of Ehrlich ascites tumor cells. Biochimie. 1985 Feb;67(2):259-64. The glycerophosphate shuttle can be ruled out because of the lack of relevant enzymatic activities, and the failure of to increase rotenone-inhibited respiration. Estimation of citrate synthase and ATP citrate lyase, in addition to the observed high activity of malate dehydrogenase, suggests a - shuttle. |
1(0,0,0,1) | Details |
| 12226375 | Moller IM, Roberts TH, Rasmusson AG: Induces External Deamino- Oxidation in Potato Tuber Mitochondria. Plant Physiol. 1996 Sep;112(1):75-78. We conclude that UQ-1-induced external deamino- oxidation is due to a change in specificity of the external rotenone-insensitive NADH dehydrogenase. |
0(0,0,0,0) | Details |