| Name | PP1 |
|---|---|
| Synonyms | NPY4 R; PP1; NPY4R; Neuropeptide Y receptor type 4; PPYR 1; PPYR1; Pancreatic polypeptide receptor 1; Y4… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18090317 | Wu YN, Martella G, Johnson SW: Rotenone enhances currents by activating a kinase in rat neurons. Neuroreport. 2007 Nov 19;18(17):1813-6. Using patch pipettes to record whole-cell currents in rat brain slices, we report that the rotenone-induced potentiation of current is blocked by the kinase inhibitors and PP1. |
81(1,1,1,1) | Details |
| 20231142 | Villa-Abrille MC, Caldiz CI, Ennis IL, Nolly MB, Casarini MJ, Chiappe de Cingolani GE, Cingolani HE, Perez NG: The Anrep effect requires transactivation of the epidermal growth factor receptor. J Physiol. 2010 Mar 15. The SFR was 123+/-1% of rapid phase (n=6, P <0.05) and was blunted by preventing EGFR transactivation with the Src-kinase inhibitor (PP1, 99+/-2%, n=4), the matrix metalloproteinase inhibitor (MMPI, 8+/-4%, n=11), by EGFR blockade (AG1478, 98+/-2%, n=6) or the mitochondrial transition pore blocker (clyclosporine, 99+/-3%, n=6). EGF increased O2- production by 149+/-4% of control (n=9, P <0.05), effect canceled by inhibiting oxidase (apocynin, 110+/-6% n=7), mKATP channels (5-HD, 105+/-5%, n=8), respiratory chain (rotenone, 110+/-7%, n=7) or MPTP (Cyclosporine, 111+/-10%, n=6). |
2(0,0,0,2) | Details |
| 15913578 | Sato H, Sato M, Kanai H, Uchiyama T, Iso T, Ohyama Y, Sakamoto H, Tamura J, Nagai R, Kurabayashi M: Mitochondrial reactive species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells. Cardiovasc Res. 2005 Sep 1;67(4):714-22. Src kinase inhibitors PP1 and PP2 inhibited hypoxia-induced HIF-1alpha protein and PAI-1 gene expression. Ablation of mitochondrial respiration by rotenone abolished hypoxia-induced ROS generation, c-Src phosphorylation, HIF-1alpha protein expression, and PAI-1 gene expression. |
1(0,0,0,1) | Details |