Protein Information

Name SREBF1
Synonyms SREBF 1; SREBF1; SREBP 1; SREBP1; Sterol regulatory element binding protein 1; Sterol regulatory element binding transcription factor 1; Sterol regulatory element binding protein 1s; Sterol regulatory element binding transcription factor 1s

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
17651460 Prigione A, Cortopassi G: Mitochondrial DNA deletions induce the adenosine monophosphate-activated protein kinase energy stress pathway and result in decreased secretion of some proteins. Aging Cell. 2007 Oct;6(5):619-30. Epub 2007 Jul 26.

The defects in ATP synthesis, induction of the AMPK and SREBF1 transcripts, and decreased expression of ARL2 and secretion of OPG and FN were recapitulated by low doses of rotenone, demonstrating that they were a specific consequence of electron transport chain inhibition.		 32(0,1,1,2) Details