Protein Information

Name PC3
Synonyms CBX 8; PC3; CBX8; Chromobox homolog 8; Chromobox homolog 8 polycomb 3; Chromobox protein homolog 8; HPC 3; HPC3…

Compound Information

Name EPN
CAS

Reference List

PubMed Abstract RScore(About this table)
17126478 Cindolo L, Franco R, Cantile M, Schiavo G, Liguori G, Chiodini P, Salzano L, Autorino R, Di Blasi A, Falsaperla M, Feudale E, Botti G, Gallo A, Cillo C: NeuroD1 expression in human prostate cancer: can it contribute to neuroendocrine differentiation comprehension?. Eur Urol. 2007 Nov;52(5):1365-73. Epub 2006 Nov 20.


METHODS: We detected NeuroD1 gene expression, by duplex reverse transcriptase-polymerase chain reaction, in primary human prostate fibroblasts, in EPN, LNCaP, DU145, and PC3 cell lines before and after cAMP exposure, in 6 BPH and 11 pCA samples.
2(0,0,0,2) Details
16267859 Chieffi P, Cozzolino L, Kisslinger A, Libertini S, Staibano S, Mansueto G, De Rosa G, Villacci A, Vitale M, Linardopoulos S, Portella G, Tramontano D: Aurora B expression directly correlates with prostate cancer malignancy and influence prostate cell proliferation. Prostate. 2006 Feb 15;66(3):326-33.


In analogy to the in vivo situation, Aurora B was vigorously expressed in the androgen independent PC cell lines PC3 and DU145, while a very modest expression of the kinase was observed in the androgen sensitive LnCap cells and in the EPN cells, a line of epithelial cells derived from normal prostate tissue.
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16763065 Pasquali D, Rossi V, Staibano S, De Rosa G, Chieffi P, Prezioso D, Mirone V, Mascolo M, Tramontano D, Bellastella A, Sinisi AA: The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy. Endocrinology. 2006 Sep;147(9):4245-51. Epub 2006 Jun 8.


EG-VEGF/PK1 was absent in androgen-independent PC3 and DU-145 cell lines.
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