| Name | muscles |
|---|---|
| Synonyms | COX 7a M; COX VIIa M; COX7A; COX7A1; COX7A1 protein; COX7AH; COX7AM; Cytochrome c oxidase subunit 7a H… |
| Name | leptophos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2472490 | Yamauchi T, Katoh K, Konno N, Fukushima M: Delayed neurotoxicity and toxicokinetics of leptophos in hens given repeatedly by low-dose intravenous injections. J Toxicol Sci. 1989 Feb;14(1):11-21. These results suggest that leptophos seems to transfer from blood to affinitive tissues such as sciatic nerve or leg muscles and to accumulate there easily in initial stage after repeated iv injections, and that this causes the enhancement of neuropathy with repeated administrations of divided critical dose of leptophos in both iv and oral administration. |
81(1,1,1,1) | Details |
| 12697382 | Piao F, Yamauchi T, Ma N: The effect of Calcicol as tonic on delayed neurotoxicity induced by organophosphorus compounds. Toxicol Lett. 2003 Jun 5;143(1):65-71. One group received formal as vehicle group, two groups received 30 mg/kg leptophos or 40 mg/kg triortho-cresyl (TOCP) (L group and T group), two groups received 2.4 mg/kg Ca (2+) (0.3 ml/kg Calcicol) 24 h before leptophos or TOCP administration, and the last two groups received 2.4 mg/kg Ca after leptophos or TOCP administration, respectively. This shows that polyneuropathy and the recovery function of nerves and muscles suffering from polyneuropathy can be alleviated, as long as tonic is administered before the clinical signs develop. |
1(0,0,0,1) | Details |
| 2413587 | Sheets L, Norton S: Peripheral nerve damage in chicks following treatment with organophosphorus compounds in ovo. Toxicol Appl Pharmacol. 1985 May;78(3):412-20. Chick embryos were treated with tri-o-cresyl (TOCP) or leptophos, organophosphorus compounds that cause delayed neurotoxicity. Consistent with the evidence of denervation there was increased terminal branching of motor axons in femoral (sartorius) and tibial (external gastrocnemius and peroneus longus) leg muscles. |
2(0,0,0,2) | Details |