| Name | beta is |
|---|---|
| Synonyms | "beta I"; Alpha II; Alpha tryptase; Beta I; Lung tryptase; Mast cell protease II; Mast cell tryptase; Pituitary tryptase… |
| Name | HCH |
|---|---|
| CAS | 1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18996566 | Zamir R, Athanasiadou M, Nahar N, Mamun MI, Mosihuzzaman M, Bergman A: Persistent organohalogen contaminants in plasma from groups of humans with different occupations in Bangladesh. Chemosphere. 2009 Jan;74(3):453-9. Epub 2008 Nov 8. Among the other pesticides analysed beta-HCH is the most abundant indicating the use of technical HCH products instead of Lindane (gamma-HCH). |
3(0,0,0,3) | Details |
| 12948864 | Zou E, Matsumura F: Long-term exposure to beta-hexachlorocyclohexane (beta-HCH) promotes transformation and invasiveness of MCF-7 human breast cancer cells. Biochem Pharmacol. 2003 Sep 1;66(5):831-40. Due to its lipophilicity and persistence, an organochlorine compound, beta-hexachlorocyclohexane (beta-HCH), is known to frequently accumulate in human adipose and breast tissues. |
2(0,0,0,2) | Details |
| 12623652 | Waliszewski SM, Villalobos-Pietrini R, Gomez-Arroyo S, Infanzon RM: Persistent organochlorine pesticide levels in cow's milk samples from tropical regions of Mexico. Food Addit Contam. 2003 Mar;20(3):270-5. Results obtained indicate that beta-HCH is one of the main contaminants (0.106 and 0.087 mg x kg (-1) on fat basis) followed by pp'-DDT (0.078 and 0.037 mg x kg (-1) on fat basis) and pp'-DDE (0.051 and 0.033 mg x kg (-1) on fat basis). |
1(0,0,0,1) | Details |
| 9299729 | Otero R, Santiago-Silva M, Grimalt JO: Hexachlorocyclohexanes in human blood serum. J Chromatogr A. 1997 Aug 22;778(1-2):87-94. The results have shown that beta-HCH is selectively accumulated in human sera and to the preferential investigation of the toxic effects of this isomer in humans and mammals. |
1(0,0,0,1) | Details |
| 9169059 | Jung D, Becher H, Edler L, Flesch-Janys D, Gurn P, Konietzko J, Manz A, Papke O: Elimination of beta-hexachlorocyclohexane in occupationally exposed persons. J Toxicol Environ Health. 1997 May;51(1):23-34. Assuming a first-order kinetic model for excretion, the median half-life of beta-HCH is 7.2 yr calculated by concentrations in whole blood and 7.6 yr calculated by concentrations in extractable lipids. |
1(0,0,0,1) | Details |
| 20061660 | Ingelido AM, Abballe A, Marra V, Valentini S, Ferro A, Porpora MG, Barbieri PG, De Felip E: Serum concentrations of beta-hexachlorocyclohexane in groups of the Italian general population: a human biomonitoring study. Ann Ist Super Sanita. 2009;45(4):401-8. Although the use of technical HCH, which is the primary source of beta-HCH in the environment, has been banned in the EU in 1978 and progressively at a global level, beta-HCH is still detectable in the general environment worldwide. |
1(0,0,0,1) | Details |
| 12450824 | Kumari R, Subudhi S, Suar M, Dhingra G, Raina V, Dogra C, Lal S, van der Meer JR, Holliger C, Lal R: Cloning and characterization of lin genes responsible for the degradation of Hexachlorocyclohexane isomers by Sphingomonas paucimobilis strain B90. Appl Environ Microbiol. 2002 Dec;68(12):6021-8. While all these isomers pose serious environmental problems, beta-HCH is more problematic due to its longer persistence in the environment. |
1(0,0,0,1) | Details |
| 20199797 | Hedley AJ, Hui LL, Kypke K, Malisch R, van Leeuwen FX, Moy G, Wong TW, Nelson EA: Residues of persistent organic pollutants (POPs) in human milk in Hong Kong. Chemosphere. 2010 Apr;79(3):259-65. Epub 2010 Mar 2. Continuous monitoring of POPs in human milk, especially beta-HCH, is needed for surveillance and interpretation of time trends, and for linkage to strict enforcement of agricultural regulations. |
1(0,0,0,1) | Details |
| 17516046 | Ito M, Prokop Z, Klvana M, Otsubo Y, Tsuda M, Damborsky J, Nagata Y: Degradation of beta-hexachlorocyclohexane by haloalkane dehalogenase LinB from gamma-hexachlorocyclohexane-utilizing bacterium Sphingobium sp. Arch Microbiol. 2007 Oct;188(4):313-25. Epub 2007 May 22. The technical formulation of hexachlorocyclohexane (HCH) mainly consists of the insecticidal gamma-isomer and noninsecticidal alpha-, beta-, and delta-isomers, among which beta-HCH is the most recalcitrant and has caused serious environmental problems. |
1(0,0,0,1) | Details |
| 19597089 | Richardson JR, Shalat SL, Buckley B, Winnik B, O'Suilleabhain P, Diaz-Arrastia R, Reisch J, German DC: Elevated serum pesticide levels and risk of Parkinson disease. . Arch Neurol. 2009 Jul;66(7):870-5. CONCLUSIONS: These data suggest that beta-HCH is associated with a diagnosis of PD. |
1(0,0,0,1) | Details |
| 16977465 | Wu J, Hong Q, Han P, He J, Li S: A gene linB2 responsible for the conversion of beta-HCH and 2,3,4,5,6-pentachlorocyclohexanol in Sphingomonas sp. Appl Microbiol Biotechnol. 2007 Jan;73(5):1097-105. Epub 2006 Sep 15. All four isomers are toxic and recalcitrant pollutants. beta-HCH is more problematic due to its longer persistence in the environment. |
1(0,0,0,1) | Details |
| 18207242 | Alvarez-Pedrerol M, Ribas-Fito N, Torrent M, Carrizo D, Garcia-Esteban R, Grimalt JO, Sunyer J: Thyroid disruption at birth due to prenatal exposure to beta-hexachlorocyclohexane. Environ Int. 2008 Aug;34(6):737-40. Epub 2008 Jan 22. CONCLUSIONS: beta-HCH is potentially a new thyroid disrupting compound, deserving special interest in future studies given its high body burden in humans. |
1(0,0,0,1) | Details |
| 8968093 | Steinmetz R, Young PC, Caperell-Grant A, Gize EA, Madhukar BV, Ben-Jonathan N, Bigsby RM: Novel estrogenic action of the pesticide residue beta-hexachlorocyclohexane in human breast cancer cells. Cancer Res. 1996 Dec 1;56(23):5403-9. However, beta-HCH is ineffective in stimulating a reporter construct driven only by a consensus response element and a minimal promoter derived from the herpes simplex virus thymidine kinase gene. |
1(0,0,0,1) | Details |