| Name | protein tyrosine kinase |
|---|---|
| Synonyms | Acidic fibroblast growth factor; Tyrosylprotein kinase; Protein tyrosine kinase; Hydroxyaryl protein kinase; CD334; CD334 antigen; FGF receptor 4; FGFR 4… |
| Name | HCH |
|---|---|
| CAS | 1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10487416 | Hatakeyama M, Matsumura F: Correlation between the activation of Neu kinase and promotion of foci formation induced by selected organochlorine compounds in the MCF-7 model system. J Biochem Mol Toxicol. 1999;13(6):296-302. In our previous study, two representative organochlorines, 1,1,1-trichloro 2-o-chlorophenyl-2'-p-chlorophenyl ethane (o,p'-DDT) and beta-1,2,3,4,5,6-hexachlorocyclohexane (beta HCH), were found to directly activate the protein tyrosine kinase of Neu (c-erbB-2 proto-oncogene product) immunoprecipitates isolated from MCF-7 breast cancer cells. |
3(0,0,0,3) | Details |
| 1715812 | Tsai WH, Zarnegar R, Michalopoulos GK: Long-term treatment with hepatic tumor promoters inhibits mitogenic responses of hepatocytes to acidic fibroblast growth factor and hepatocyte growth factor. Cancer Lett. 1991 Aug;59(2):103-8. |
2(0,0,0,2) | Details |
| 9443065 | Enan E, Matsumura F: Activation of c-Neu kinase by o,p'-DDT and beta-HCH in cell-free and intact cell preparations from MCF-7 human breast cancer cells. J Biochem Mol Toxicol. 1998;12(2):83-92. Moreover, these organochlorines were found to activate PTK even under cell-free conditions, indicating that they are likely to interact directly with the target protein tyrosine kinase. |
1(0,0,0,1) | Details |