| Name | transferase |
|---|---|
| Synonyms | 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80… |
| Name | aldrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9928623 | Bomhard EM, Schmidt U, Loser E: Time course of enzyme induction in liver and kidneys and absorption, distribution and elimination of 1,4-dichlorobenzene in rats. Toxicology. 1998 Nov 16;131(2-3):73-91. The monoxygenases 7-ethoxycoumarin O-deethylase (ECOD), 7-ethoxyresorufin O-deethylase (EROD) and aldrin epoxidase (ALD) as well as the phase II enzymes; epoxide hydrolase (EH), glutathione S-transferase (GS-T) and glucuronyl transferase (GLU-T) were dose-dependently induced in the liver of males and females. |
6(0,0,1,1) | Details |
| 2890477 | Peakall DB, Jeffrey DA, Boersma D: Mixed-function oxidase activity in seabirds and its relationship to oil pollution. Comp Biochem Physiol C. 1987;88(1):151-4. The hepatic activity of epoxide hydrolase, aldrin epoxidase, aminopyrine N-demethylase, 7-ethoxyresorufin O-deethylase, benzo (a) pyrene 3-hydroxylase and UDP glucuronyl transferase was determined in adult herring gulls (Larus argentatus) at various stages of the breeding season. 2. |
6(0,0,1,1) | Details |
| 8471063 | Borlakoglu JT, Scott A, Henderson CJ, Jenke HJ, Wolf CR: Transplacental transfer of polychlorinated biphenyls induces simultaneously the expression of P450 isoenzymes and the protooncogenes c-Ha-ras and c-raf. Biochem Pharmacol. 1993 Apr 6;45(7):1373-86. Concomitantly, the metabolism of nitroanisole, ethoxyresorufin and benzo [a] pyrene was significantly increased, but foetal metabolism of dimethylnitrosamine was not detectable and only marginal increases in the metabolism of aminopyrine and aldrin were seen. Further measurements show significant increases in foetal and maternal epoxide hydrolase, glutathione-S-transferase and UDP-glucuronyl transferase activities, thus suggesting that treatment with Aroclor 1254 resulted in coordinated increases in foetal and maternal oxidative and post-oxidative drug metabolism. |
1(0,0,0,1) | Details |
| 12011480 | Wade MG, Parent S, Finnson KW, Foster W, Younglai E, McMahon A, Cyr DG, Hughes C: Thyroid toxicity due to subchronic exposure to a complex mixture of 16 organochlorines, lead, and cadmium. Toxicol Sci. 2002 Jun;67(2):207-18. To investigate the potential effects of a complex, environmentally relevant mixture on the HPT axis, sexually mature male rats were administered a mixture of 16 common organochlorines (dichlorodiphenoxytrichloroethane [DDT], p,p'-dichlorodiphenoxydichloroethylene [p,p'-DDE], hexachlorobenzene [HCB], tetrachlorodibenzo-p-dioxin [TCDD], polychlorinated biphenyls [PCBs], methoxychlor, endosulfan, heptachlor, hexachlorocyclohexane, dieldrin, aldrin, mirex, and several chlorinated benzenes, and metal contaminants [lead, cadmium]). After 70 daily treatments by gavage, endpoints related to circulating thyroid hormone (serum [T (4)], [T (3)], thyroid stimulating hormone [TSH], and serum T (3) uptake [T (3)-up]), thyroid gland histomorphology (thyroid follicle cross sectional area, epithelial height, follicle roundness or aspect ratio, colloid/epithelial ratio) and hepatic metabolism of thyroid hormone (UDP-glucuronyl transferase [UGT] and outer-ring deiodinase [ORD]) were assessed. |
1(0,0,0,1) | Details |
| 7117752 | Kurata M, Hirose K, Umeda M: Inhibition of metabolic cooperation in Chinese hamster cells by organochlorine pesticides. Gann. 1982 Apr;73(2):217-21. Effects of organochlorine pesticides on the metabolic cooperation in the --phosphoribosyl-transferase system using wild-type 6-thioguanine-sensitive V79 cells and variant 6-thioguanine-resistant cells were surveyed. The metabolic cooperation was inhibited by 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT), 1,1-dichloro-2,2-bis (p-chlorophenyl) ethane (TDE), 1,1,1-trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl) ethane (o,p'-DDT), 1,1,1-trichloro-2,2-bis (p-methoxyphenyl) ethane (methoxychlor), aldrin, dieldrin, endrin, heptachlor, alpha-isomer of benzene hexachloride (alpha-BHC), and gamma-BHC, but not beta-BHC. |
1(0,0,0,1) | Details |
| 107617 | Riviere JL, De Lavaur E, Grolleau G: Effect of polychlorinated biphenyls on drug metabolism in Japanese quail and its progeny. Toxicology. 1978 Dec;11(4):329-34. PCB (DP5, 1 and 5 mg/female/day, orally for 40 days) induce microsomal hepatic enzymes (cytochrome P-450, hydroxylase, aldrin epoxidase, p-nitroanisole demethylase, UDPGA-transferase) in adult female Japanese quail. |
6(0,0,1,1) | Details |
| 739217 | Stott WT, Sinnhuber RO: Dietary protein levels and aflatoxin B metabolism in rainbow trout (Salmo gairdneri). J Environ Pathol Toxicol. 1978 Nov-Dec;2(2):379-88. Fish fed diets containing 32 percent, 52 percent and 62 percent fish protein concentrate (FPC) were examined for hepatic cytochrome P-450 content and in vitro cytochrome c reductase, -S-epoxide transferase (GTr), epoxide hydrase (EH) and aldrin epoxidase (AE) activity. |
6(0,0,1,1) | Details |
| 3934854 | Krupski G, Kiefer F, Wiebel FJ: Variability in the expression of xenobiotic-metabolizing enzymes during the growth cycle of rat hepatoma cells. Xenobiotica. 1985 Aug-Sep;15(8-9):781-7. Cytochrome P-450-dependent aldrin epoxidase activity showed a peak on day 3 after plating of cells and decreased by more than 90% during the following six days. Glutathione S-transferase and UDP-glucuronosyl transferase with 4-hydroxybiphenyl as substrate also showed decreases in their activities towards the later phase of the growth cycle, although to lesser extents than the mono-oxygenase. |
2(0,0,0,2) | Details |
| 11701388 | Bayoumi AE, Garcia-Fernandez AJ, Ordonez C, Perez-Pertejo Y, Cubria JC, Reguera RM, Balana-Fouce R, Ordonez D: Cyclodiene organochlorine insecticide-induced alterations in the -redox cycle in CHO-K1 cells. Comp Biochem Physiol C Toxicol Pharmacol. 2001 Nov;130(3):315-23. The effect of the cyclodiene organochlorine pesticides aldrin, dieldrin and endosulfan was assessed on CHO-K1 cultures at fractions of their lethal doses, determined by the neutral red (NRI) incorporation assay (NRI6.25, NRI12.5 and NRI25). peroxidase, reductase and S-transferase, and total and oxidised were evaluated along the standard growth curve of the cultures. |
2(0,0,0,2) | Details |
| 2599155 | Schmidt U, Machemer L: Difference between species in response to a 3,5-dichloropyridyloxyphenoxy compound: induction of cytochrome P-450 and/or peroxisome proliferation. Food Addit Contam. 1989;6 Suppl 1:S41-55. In order to answer the question of whether peroxisome proliferation is the second mechanism for affecting liver, the acetyl transferase activity (CA-T), a marker enzyme for peroxisome proliferation, was determined in all liver samples from the comparative species studies. The evaluation of the enzyme activity results showed an unusually severe dose-related induction of the monooxygenases [7-ethoxycoumarin-O-deethylase (EOD), 7-ethoxyresorufin-O-deethylase (EOR) and aldrin epoxidase (ALD)] in the mouse and a much weaker reaction in the other species tested. |
1(0,0,0,1) | Details |