Protein Information

Name true cholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name phosphamidon
CAS 2-chloro-3-(diethylamino)-1-methyl-3-oxo-1-propenyl dimethyl phosphate

Reference List

PubMed Abstract RScore(About this table)
1833318 Rao KV, Ghouselazam S, Surendranath P: Inhibition and recovery of selected target enzyme activities in tissues of penaeid prawn, Metapenaeus monoceros (Fabricius), exposed to different insecticides. Indian J Exp Biol. 1991 May;29(5):489-91.

The target enzymes, acetylcholinesterase (for phosphamidon and carbaryl) and Mg2+ ATPase (for DDT and fenvalerate) have been assayed during exposure and reclamation of these insecticides in M. monoceros.
31(0,1,1,1) Details
3382792 Reddy MS, Rao KV: In vivo recovery of acetylcholinesterase activity from phosphamidon and methylparathion induced inhibition in the nervous tissue of penaeid prawn (Metapenaeus monoceros). Bull Environ Contam Toxicol. 1988 May;40(5):752-8.
31(0,1,1,1) Details
18569613 Rajini PS, Melstrom P, Williams PL: A comparative study on the relationship between various toxicological endpoints in Caenorhabditis elegans exposed to organophosphorus insecticides. J Toxicol Environ Health A. 2008;71(15):1043-50.

The toxicity of 10 organophophorus (OP) insecticides-acephate, dimethoate, dichlorvos, dicrotophos, monocrotophos, methamidophos, phosphamidon, omethoate, phosdrin, and trichlorfon-was evaluated in Caenorhabditis elegans using lethality, movement, and acetylcholinesterase (AChE) activity as the endpoints after a 4-hr- exposure period.
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10509429 Abdelsalam EB: Neurotoxic potential of six organophosphorus compounds in adult hens. Vet Hum Toxicol. 1999 Oct;41(5):290-2.

The neurotoxic potential of trichlorfon, diazinon, phosmet, dichlorvos, phosphamidon and coumaphos was evaluated for their ability to inhibit brain neurotoxic esterase (NTE) activity in adult hens.
All compounds were administered at high single oral doses and the NTE and acetylcholinesterase (AchE) activities were measured at 24 h and 6 w later.
1(0,0,0,1) Details
1877982 Reddy MS, Rao KV: Phosphamidon, methylparathion and dichlorvos impact on tissue oxidative metabolism in penaeid prawn, Metapenaeus monoceros. Biochem Int. 1991 Feb;23(3):439-47.

The OPI are found to inhibit the activity levels of acetylcholinesterase, succinate dehydrogenase, isocitrate dehydrogenase, pyruvate dehydrogenase, lactate dehydrogenase and cytochrome-c-oxidase and cause accumulation of acetylcholine in the hepatopancreas and muscle tissues.
1(0,0,0,1) Details
16042503 Lotti M, Moretto A: Organophosphate-induced delayed polyneuropathy. . Toxicol Rev. 2005;24(1):37-49.

The ratio of inhibitory powers for acetylcholinesterase and NTE represents the crucial guideline for the aetiological attribution of OP-induced peripheral neuropathy.
In this article, we mainly discuss OP pesticide poisoning, particularly when caused by chlorpyrifos, dichlorvos, isofenphos, methamidophos, mipafox, trichlorfon, trichlornat, phosphamidon/mevinphos and by certain carbamates.
1(0,0,0,1) Details
356519 Szamosujvari P, Szabo J, Nosztray K, Szegi J: [Effect of diazepam (Seduxen) on true cholinesterase activity] Acta Pharm Hung. 1978 May;48(3):138-44.

1(0,0,0,1) Details
7927563 Datta C, Gupta J, Sengupta D: Interaction of organophosphorus insecticides phosphamidon & malathion on lipid profile & acetylcholinesterase activity in human erythrocyte membrane. Indian J Med Res. 1994 Aug;100:87-9.

The organophosphorus insecticides phosphamidon and malathion were found to inhibit the activity of human acetylcholinesterase in vitro, in the human erythrocyte membrane.
113(1,2,2,3) Details
7495383 Jokanovic M, Maksimovic M, Stepanovic RM: Interaction of phosphamidon with neuropathy target esterase and acetylcholinesterase of hen brain. Arch Toxicol. 1995;69(6):425-8.
86(1,1,1,6) Details
8783813 Worek F, Kirchner T, Backer M, Szinicz L: Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds. Arch Toxicol. 1996;70(8):497-503.

For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control.
84(1,1,1,4) Details
3721551 Chattopadhyay R, Choudhuri DK, Maity CR: In vitro inhibition of brain acetylcholinesterase by phosphamidon & physostigmine sulphate in adult chick. Indian J Med Res. 1986 Apr;83:435-40.
81(1,1,1,1) Details
5763647 Braid PE, Nix M: The kinetic constants for the inhibition of acetylcholinesterase by phosdrin, sumioxon, DDVP, and phosphamidon. Can J Biochem. 1969 Jan;47(1):1-6.
81(1,1,1,1) Details