Name | protein kinase A (protein family or complex) |
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Synonyms | Protein kinase A; cAMP dependent protein kinase; cAMP dependent protein kinases |
Name | IBA |
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CAS |
PubMed | Abstract | RScore(About this table) | |
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1313168 | Doupnik CA, Pun RY: Cyclic AMP-dependent phosphorylation modifies the gating properties of L-type Ca2+ channels in bovine chromaffin cells. Pflugers Arch. 1992 Jan;420(1):61-71. Extracellular perfusion with the membrane-permeant activator of cAMP-dependent protein kinase, 8-bromo (8-Br)-cAMP (1 mM), caused a 49%, 29%, and 21% increase in Ca2+ current (ICa) amplitudes evoked by voltage steps to 0, +10, and +20 mV respectively (mean values from eight cells, p less than or equal to 0.05). The membrane potential for half activation (V1/2) was also significantly shifted 6 mV more negative for IBa (mean, n = 8). |
1(0,0,0,1) | Details |
9594024 | Allen TJ, Mikala G: Effects of temperature on human L-type cardiac Ca2+ channels expressed in Xenopus oocytes. Pflugers Arch. 1998 Jul;436(2):238-47. Temperature normally affects peak L-type Ca2+ channel (CaCh) current with a temperature coefficient (Q10) of between 1.8 and 3.5; in cardiomyocytes attenuating protein kinase A activity increases Q10 whilst activating it lowers Q10. Peak inward currents (IBa) through expressed CaChs (i.e. alpha1C alpha2/deltaa beta1b) exhibited a Q10 of 5.8+/-0.4 when examined between 15 and 25 degreesC. |
1(0,0,0,1) | Details |
1371671 | Lory P, Nargeot J: Cyclic AMP-dependent modulation of cardiac Ca channels expressed in Xenopus laevis oocytes. Biochem Biophys Res Commun. 1992 Feb 14;182(3):1059-65. Inhibition of protein kinase A (PKA) dramatically reduced the Ba current amplitude, indicating that cAMP-dependent modulation plays an important role in maintaining the basal activity of expressed Ca channels. |
1(0,0,0,1) | Details |
7491257 | Zong X, Schreieck J, Mehrke G, Welling A, Schuster A, Bosse E, Flockerzi V, Hofmann F: On the regulation of the expressed L-type calcium channel by cAMP-dependent phosphorylation. Pflugers Arch. 1995 Jul;430(3):340-7. The peak Ba2+ current (IBa) of these cells was not affected significantly by internal dialysis with 0.1 mM cAMP-dependent protein kinase inhibitor peptide (mPKI), 25 microM cAMP-dependent protein kinase catalytic subunit (PKA), or a combination of 25 microM PKA and 1 microM okadaic acid. |
0(0,0,0,0) | Details |
9789110 | Sunagawa M, Yokoshiki H, Seki T, Sperelakis N: Intracellular application of calmidazolium increases Ca2+ current through activation of protein kinase A in cultured vascular smooth muscle cells. J Vasc Res. 1998 Sep-Oct;35(5):303-9. On the other hand, the CMZ stimulation of IBa was prevented by both H-7, a nonspecific protein kinase inhibitor, and H-89, a specific inhibitor of protein kinase A (PK-A). |
82(1,1,1,2) | Details |
7900772 | Yuan W, Bers DM: Protein kinase inhibitor H-89 reverses forskolin stimulation of cardiac L-type current. Am J Physiol. 1995 Mar;268(3 Pt 1):C651-9. The acceleration is likely to be due to greater Ca-dependent inactivation of ICa, where the slowing of IBa inactivation may be due to protein kinase A-dependent slowing of Em-dependent inactivation. |
81(1,1,1,1) | Details |
10226153 | Zhong J, Dessauer CW, Keef KD, Hume JR: Regulation of L-type Ca2+ channels in rabbit portal vein by G protein alphas and betagamma subunits. J Physiol. 1999 May 15;517 ( Pt 1):109-20. The stimulatory effect of Galphas on peak IBa was entirely abolished by the protein kinase A inhibitor Rp-8-Br-cAMPS, or the adenylyl cyclase inhibitor SQ 22536. |
32(0,1,1,2) | Details |
9062905 | Van Coppenolle F, Ahidouch A, Guilbault P, Ouadid H: Regulation of endogenous Ca2+ channels by cyclic AMP and cyclic GMP-dependent protein kinases in Pleurodeles oocytes. Mol Cell Biochem. 1997 Mar;168(1-2):155-61. This effect on IBa was blocked by the injection of protein kinase A inhibitor. |
32(0,1,1,2) | Details |
17397827 | Walsh KB, Zhang J, Fuseler JW, Hilliard N, Hockerman GH: Adenoviral-mediated expression of dihydropyridine-insensitive L-type channels in cardiac ventricular myocytes and fibroblasts. Eur J Pharmacol. 2007 Jun 22;565(1-3):7-16. Epub 2007 Mar 3. Furthermore, addition of 2 microM forskolin and 100 microM 3-isobutyl-1-methylxanthine (IBMX), to stimulate protein kinase A, strongly increased IBa in the AdCaV1.2DHPi-infected cells. |
6(0,0,1,1) | Details |
9490807 | Allen TJ, Mikala G, Wu X, Dolphin AC: Effects of In previous studies on L-type Ca2+ channel currents in cardiomyocytes and dorsal root ganglia, the inhibitory effects of BDM were attenuated by activation of protein kinase A. 2. Ba2+ currents (IBa) through a human wild-type L-type Ca2+ channel complex (i.e. halpha1C, alpha2-deltaa and hbeta1b) are inhibited by BDM with an IC50 of 16 mM, with 10 mM producing a 36.1 +/- 2.2 % inhibition. |
monoxime (BDM) on channels expressed in Xenopus oocytes. J Physiol. 1998 Apr 1;508 ( Pt 1):1-14.1(0,0,0,1) | Details |
7535119 | Kaneko S, Fukuda K, Yada N, Akaike A, Mori Y, Satoh M: Ca2+ channel inhibition by kappa opioid receptors expressed in Xenopus oocytes. Neuroreport. 1994 Dec 20;5(18):2506-8. Perfusion of the oocytes with U50488H inhibited depolarization-evoked Ba2+ current (IBa) in a reversible manner, showing maximal inhibition of 25% at 1 microM (IC50 = 31 nM). These findings suggest that kappa opioid receptors inhibit the activity of neuronal Ca2+ channels via GTP-binding proteins, without the participation of protein kinase A or C. |
1(0,0,0,1) | Details |
11179395 | Zhong J, Hume JR, Keef KD: beta-Adrenergic receptor stimulation of L-type Ca2+ channels in rabbit portal vein myocytes involves both alphas and betagamma G protein subunits. J Physiol. 2001 Feb 15;531(Pt 1):105-15. Previous studies have shown that purified G protein alphas and betagamma subunits stimulate vascular L-type Ca2+ channels through protein kinase A and C (PKA and PKC), respectively. Peak Ba2+ current (IBa) in freshly isolated rabbit portal vein smooth muscle cells was significantly increased by bath application of 0.5 microM isoproterenol (isoprenaline; ISO) when measured using the whole-cell patch clamp method (53 +/- 3 % increase, n = 15). |
1(0,0,0,1) | Details |
2435866 | Leonard JP, Nargeot J, Snutch TP, Davidson N, Lester HA: Ca channels induced in Xenopus oocytes by rat brain mRNA. J Neurosci. 1987 Mar;7(3):875-81. IBa in noninjected oocytes was often undetectable, but ranged up to 50 nA (22 +/- 4 nA, n = 21). |
0(0,0,0,0) | Details |