Protein Information

Name AT1
Synonyms AG2S; AT1; AGTR 1; AGTR1; AGTR1A; AGTR1B; AT1AR; AT1B…

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
11302725 Matsubara H, Shibasaki Y, Okigaki M, Mori Y, Masaki H, Kosaki A, Tsutsumi Y, Uchiyama Y, Fujiyama S, Nose A, Iba O, Tateishi E, Hasegawa T, Horiuchi M, Nahmias C, Iwasaka T: Effect of angiotensin II type 2 receptor on tyrosine kinase Pyk2 and c-Jun NH2-terminal kinase via SHP-1 tyrosine phosphatase activity: evidence from vascular-targeted transgenic mice of AT2 receptor. Biochem Biophys Res Commun. 2001 Apr 20;282(5):1085-91.


Angiotensin II (Ang II) has two major receptor isoforms, AT1 and AT2.
3(0,0,0,3) Details
12397683 Matsubara H, Fujiyama S, Iba O, Amano K, Iwasaka T: [Angiogenesis and angiotensin II: differential postnatal angiogenic activities unmasked by gene-engineered mouse models of angiotensin AT1 and AT2 receptor subtypes]. Nippon Rinsho. 2002 Oct;60(10):1911-5.

2(0,0,0,2) Details
12511537 Kurisu S, Ozono R, Oshima T, Kambe M, Ishida T, Sugino H, Matsuura H, Chayama K, Teranishi Y, Iba O, Amano K, Matsubara H: Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis. Hypertension. 2003 Jan;41(1):99-107.


The amount of cardiac AT2 receptor relative to AT1 receptor in transgenic mice was 22% to 37%.
1(0,0,0,1) Details
7516687 Shapiro MS, Wollmuth LP, Hille B: Angiotensin II inhibits calcium and M current channels in rat sympathetic neurons via G proteins. Neuron. 1994 Jun;12(6):1319-29.

This inhibition was blocked by the AT1 receptor antagonist losartan, attenuated by inclusion of 2 mM GDP-beta-S in the pipette, mostly pertussis toxin insensitive, half-sensitive to N-ethylmaleimide, and wholly voltage independent.
IBa from cell-attached patches was reduced by bath-applied angioII (mean 33%), suggesting use of a diffusible cytoplasmic messenger.
1(0,0,0,1) Details