Protein Information

Name IK1
Synonyms IK1; IKCA 1; IKCA1; Intermediate conductance calcium activated potassium channel protein 4; KCA 4; KCA4; KCNN 4; KCNN4…

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
9598592 Zaza A, Rocchetti M, Brioschi A, Cantadori A, Ferroni A: Dynamic Ca2+-induced inward rectification of K+ current during the ventricular action potential. Circ Res. 1998 May 18;82(9):947-56.

Subtraction currents obtained during blockade of K+ currents by either 1 mmol/L Ba2+ (IBa) or K+-free solution (I0K) were used to estimate IK1.
34(0,1,1,4) Details
9335409 Zhang S, Sawanobori T, Hirano Y, Hiraoka M: Multiple modulations of action potential duration by different calcium channel blocking agents in guinea pig ventricular myocytes. J Cardiovasc Pharmacol. 1997 Oct;30(4):489-96.

Whereas Mn2+ suppressed IBa without changing its decay time course, verapamil and nisoldipine speeded up the IBa decay with suppressed amplitude of IBa.
Applications of Mn2+ and verapamil suppressed amplitudes of the L-type Ca2+ current (ICa), the delayed outward K+ current (IK), and the inward rectifier K+ current (IK1).
2(0,0,0,2) Details