Protein Information

Name adenylyl cyclase
Synonyms ADCY 7; ATP pyrophosphate lyase; Adenylyl cyclase; ADCY7; ADCY7 protein; ATP pyrophosphate lyase 7; Adenylate cyclase 7; Adenylate cyclase type 7…

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
1653319 Dolphin AC: Ca2+ channel currents in rat sensory neurones: interaction between guanine nucleotides, cyclic AMP and Ca2+ channel ligands. J Physiol. 1991 Jan;432:23-43.

It is likely that forskolin enhances IBa, GTP gamma S by increasing activated Gs coupling to adenylyl cyclase and increasing cyclic AMP generation.
81(1,1,1,1) Details
10226153 Zhong J, Dessauer CW, Keef KD, Hume JR: Regulation of L-type Ca2+ channels in rabbit portal vein by G protein alphas and betagamma subunits. J Physiol. 1999 May 15;517 ( Pt 1):109-20.

The stimulatory effect of Galphas on peak IBa was entirely abolished by the protein kinase A inhibitor Rp-8-Br-cAMPS, or the adenylyl cyclase inhibitor SQ 22536.
31(0,1,1,1) Details
8772132 Tiaho F, Nerbonne JM: VIP and secretin augment cardiac L-type calcium channel currents in isolated adult rat ventricular myocytes. Pflugers Arch. 1996 Sep;432(5):821-30.

VIP also exerts a positive inotropic effect on the intact heart and enhances adenylyl cyclase activity in isolated heart membranes.
Using the whole-cell patch-clamp technique, we show here that VIP enhances Ca2+ and Ba2+ currents (IBa) through voltage-dependent L-type Ca2+ channels in adult rat ventricular myocytes.
1(0,0,0,1) Details