Protein Information

Name brain derived neurotrophic factor
Synonyms Abrineurin; BDNF; Brain derived neurotrophic factor; Brain derived neurotrophic factor precursor; Neurotrophin; Brain derived neurotrophic factors; Brain derived neurotrophic factor precursors; Neurotrophins

Compound Information

Name deltamethrin
CAS

Reference List

PubMed Abstract RScore(About this table)
16310970 Tsai SJ: Deltamethrin, a pyrethroid insecticide, could be a potential antidepressant agent. Med Hypotheses. 2006;66(3):605-8. Epub 2005 Nov 28.

With recent evidence that the activation of the BDNF-dependent pathway plays an important role in the mechanism of antidepressant therapeutic action, deltamethrin or derivatives thereof could have potential antidepressant therapeutic effects.
87(1,1,2,2) Details
16166269 Imamura L, Yasuda M, Kuramitsu K, Hara D, Tabuchi A, Tsuda M: Deltamethrin, a pyrethroid insecticide, is a potent inducer for the activity-dependent gene expression of brain-derived neurotrophic factor in neurons. J Pharmacol Exp Ther. 2006 Jan;316(1):136-43. Epub 2005 Sep 15.

Addition of deltamethrin to rat cortical cells in culture markedly increased the expression of BDNF exon III-V mRNA and protein, dependent upon the neuronal activity accompanying the influx of Ca (2+) into neurons and the Ca (2+) influx-dependent phosphorylation of extracellular signal-regulated kinases 1/2.
56(0,1,5,6) Details
12760793 Wang SQ, Shi N, Zhou L, Wu YT, Li T, Dong J, Chen L: [Brain-derived neurotrophic factor mRNA expressions in rat brain induced by short-term in vivo exposure to deltamethrin]. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Jan;37(1):33-6.
11(0,0,1,6) Details