Protein Information

Name calcium channel (protein family or complex)
Synonyms calcium channel

Compound Information

Name deltamethrin
CAS

Reference List

PubMed Abstract RScore(About this table)
14563173 de Ondarza J, Symington SB, Van Houten JL, Clark JM: G-protein modulators alter the swimming behavior and calcium influx of Paramecium tetraurelia. J Eukaryot Microbiol. 2003 Sep-Oct;50(5):349-55.

To determine whether G-proteins exert their effect via the ciliary voltage-sensitive calcium channel, we examined responses of P. tetraurelia to the potent voltage-sensitive calcium channel agonist, deltamethrin.
81(1,1,1,1) Details
8089431 Kadous A, Matsumura F, Enan E: High affinity binding of 3H-verapamil to rat brain synaptic membrane is antagonized by pyrethroid insecticides. J Environ Sci Health B. 1994 Sep;29(5):855-71.

Deltamethrin is a powerful neuroactive agent causing increased neurotransmitter release at the synapse.
To understand the cause for such an action of this pyrethroid insecticide, we have studied its binding characteristics to the calcium channel by utilizing 3H-verapamil as a specific ligand.
1(0,0,0,1) Details
18383452 Clark JM, Symington SB: Neurotoxic implications of the agonistic action of CS-syndrome pyrethroids on the N-type Ca (v) 2.2 calcium channel. Pest Manag Sci. 2008 Jun;64(6):628-38.

BACKGROUND: Cismethrin (T-syndrome) and deltamethrin (CS-syndrome) pyrethroids have been previously shown to increase membrane depolarization and calcium influx, but only deltamethrin increased Ca (2+)-dependent neurotransmitter release from rat brain synaptosomes.
1(0,0,0,1) Details
2546560 Clark JM, Brooks MW: Role of ion channels and intraterminal calcium homeostasis in the action of deltamethrin at presynaptic nerve terminals. Biochem Pharmacol. 1989 Jul 15;38(14):2233-45.

Tetrodotoxin (10 (-7) M), a sodium channel blocker, inhibited 48% of this pulsed release, and D595 (10 (-5) M), a phenethylamine-type calcium channel blocker, inhibited 21%.
1(0,0,0,1) Details
16678264 Meyer DA, Shafer TJ: Permethrin, but not deltamethrin, increases spontaneous glutamate release from hippocampal neurons in culture. Neurotoxicology. 2006 Jul;27(4):594-603. Epub 2006 Mar 28.

0(0,0,0,0) Details