Protein Information

Name Cytochrome c oxidase (protein family or complex)
Synonyms COX; cytochrome c oxidase; cytochrome c oxidases

Compound Information

Name deltamethrin
CAS

Reference List

PubMed Abstract RScore(About this table)
17304643 Chen D, Huang X, Liu L, Shi N: Deltamethrin induces mitochondrial membrane permeability and altered expression of cytochrome C in rat brain. J Appl Toxicol. 2007 Jul-Aug;27(4):368-72.

The results of the study demonstrated that deltamethrin induced a decreased mitochondrial membrane potential and increased permeability, and reduced the expression of cytochrome c, thus depressing the activity of cytochrome c oxidase significantly.
88(1,1,2,3) Details
19496430 Pridgeon JW, Becnel JJ, Clark GG, Linthicum KJ: Permethrin induces overexpression of multiple genes in Aedes aegypti. J Med Entomol. 2009 May;46(3):580-7.

These eight genes include three functionally known genes (cytochrome c oxidase subunit III, NADH2 dehydrogenase, deltamethrin resistance associated protein), three functionally unknown genes (Ae. aegypti putative 16.9-kDa secreted protein, Anopheles gambiae ENSANGP00000019508, Cryptococcus neoformans hypothetical protein CNE05340), and two novel genes.
31(0,1,1,1) Details
2632242 Catinot R, Hoellinger H, Pfister A, Sonnier M, Simon MT: Effects on rats of subacute intoxication with deltamethrin via an osmotic pump. Drug Chem Toxicol. 1989 Sep-Dec;12(3-4):173-96.

Succinate cytochrome c reductase, citrate synthase and cytochrome c oxidase were essayed, only this last showed a significant enhancement in deltamethrin treated rats.
6(0,0,1,1) Details
16824334 Chen D, Shi N, Huang XW, Liu LL: [Effects of deltamethrin on permeability of mitochondrial membrane and expression of cytochrome C in brain tissue of rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Jun;24(6):326-9.

The mitochondria in brain tissue of rats were extracted to measure the membrane permeability and the activity of cytochrome C oxidase as well as the expression of cytochrome C in cortex and hippocampus.
2(0,0,0,2) Details