| Name | chloride channel (protein family or complex) |
|---|---|
| Synonyms | chloride channel |
| Name | deltamethrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19766671 | Breckenridge CB, Holden L, Sturgess N, Weiner M, Sheets L, Sargent D, Soderlund DM, Choi JS, Symington S, Clark JM, Burr S, Ray D: Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides. Neurotoxicology. 2009 Nov;30 Suppl 1:S17-31. Epub 2009 Sep 18. Four of six alpha-cyano pyrethroids (lambda-cyfluthrin, cypermethrin, deltamethrin and fenpropathrin) reduced open chloride channel probability. |
82(1,1,1,2) | Details |
| 10662599 | Forshaw PJ, Lister T, Ray DE: The role of voltage-gated channels in type II pyrethroid insecticide poisoning. Toxicol Appl Pharmacol. 2000 Feb 15;163(1):1-8. These results support the hypothesis that the voltage-dependent chloride channel is a toxicologically significant additional site of action for deltamethrin and that the use of chloride channel agonists can provide a rationale for a novel and effective therapy against type II pyrethroid poisoning. |
32(0,1,1,2) | Details |
| 8383811 | Forshaw PJ, Lister T, Ray DE: Inhibition of a neuronal voltage-dependent chloride channel by the type II pyrethroid, deltamethrin. Neuropharmacology. 1993 Feb;32(2):105-11. |
31(0,1,1,1) | Details |
| 9339822 | Ray DE, Sutharsan S, Forshaw PJ: Actions of pyrethroid insecticides on voltage-gated channels in neuroblastoma cells. Neurotoxicology. 1997;18(3):755-60. Following our previous demonstration of actions of deltamethrin on the voltage-gated chloride channel in rats and in neuroblastoma cells, we examined the dose-response relationship for deltamethrin by patch clamp analysis of voltage-gated channels in partially differentiated NIE115 cells. |
7(0,0,1,2) | Details |
| 14657519 | Burr SA, Ray DE: Structure-activity and interaction effects of 14 different pyrethroids on voltage-gated ion channels. Toxicol Sci. 2004 Feb;77(2):341-6. Epub 2003 Dec 2. It therefore appears clear that in some combinations the type I and type II pyrethroids can compete and may bind to the same chloride channel target site. We have proposed that since the type II pyrethroids deltamethrin and cypermethrin, but not the type I pyrethroid cismethrin act on channels, this could contribute to the bimodal nature of pyrethroid poisoning syndromes. |
1(0,0,0,1) | Details |
| 2458984 | Ogata N, Vogel SM, Narahashi T: Lindane but not deltamethrin blocks a component of -activated channels. FASEB J. 1988 Oct;2(13):2895-900. The results suggest a multiplicity of the GABAA receptor-chloride channel complex. |
1(0,0,0,1) | Details |
| 1722072 | Narahashi T: Transmitter-activated ion channels as the target of chemical agents. Adv Exp Med Biol. 1991;287:61-73. The type II pyrethroids deltamethrin and fenvalerate augmented the -activated peak current when applied concurrently with but the effect was diminished as the pyrethroids were applied for long periods of time prior to application. The -activated chloride channel has been shown to be modulated by general anesthetics, and the pyrethroid, cyclodiene and lindane insecticides. |
1(0,0,0,1) | Details |
| 1787887 | Eshleman AJ, Murray TF: Pyrethroid insecticides indirectly inhibit -dependent 36Cl- influx in synaptoneurosomes from the trout brain. Neuropharmacology. 1991 Dec;30(12A):1333-41. Deltamethrin, (1R alpha S)-cis-cypermethrin and permethrin produced a dose-dependent increase in the basal uptake and a corresponding decrease in -dependent influx, with a maximum inhibition of 70-82%. Thus, pyrethroid insecticides may interfere with the function of GABAA receptors indirectly through an interaction with the voltage-dependent sodium channel in the brain of the trout and consequently perturb influx, possibly through a voltage-dependent chloride channel. |
1(0,0,0,1) | Details |