Protein Information

Name NMDA receptor (protein family or complex)
Synonyms Glutamate [NMDA] receptor; Glutamate [NMDA] receptors; N methyl D aspartate receptor; N methyl D aspartate receptors; NMDA receptor; NMDA receptors

Compound Information

Name deltamethrin
CAS

Reference List

PubMed Abstract RScore(About this table)
9037753 Robello M, Amico C, Cupello A: A dual mechanism for impairment of GABAA receptor activity by NMDA receptor activation in rat cerebellum granule cells. Eur Biophys J. 1997;25(3):181-7.

The NMDA effect was reduced by including adenosine-5'-O-3-thiophosphate (ATP-gamma-S) in the internal solution and there was a reduction in the NMDA effect caused by deltamethrin, a calcineurin inhibitor.
1(0,0,0,1) Details
16457470 Zielinska E, Kocki T, Saran T, Borbely S, Kuc D, Vilagi I, Urbanska EM, Turski WA: Effect of pesticides on kynurenic acid production in rat brain slices. Ann Agric Environ Med. 2005;12(2):177-9.

Kynurenic acid (KYNA) is a broad spectrum antagonist of ionotropic glutamate receptors, preferentially active at the strychnine-insensitive glycine allosteric site of the N-methyl-D-aspartate (NMDA) receptor, and a noncompetitive antagonist of alpha7 nicotinic receptor.
Pyrethroids, deltamethrin and fenpropathrin significantly lowered KYNA production.
1(0,0,0,1) Details
19721373 Morikawa T, Furuhama K: Effects of the NMDA receptor antagonists on deltamethrin-induced striatal dopamine release in conscious unrestrained rats. J Vet Med Sci. 2009 Aug;71(8):1129-32.
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12573543 Wu A, Liu Y: Prolonged expression of c-Fos and c-Jun in the cerebral cortex of rats after deltamethrin treatment. Brain Res Mol Brain Res. 2003 Jan 31;110(1):147-51.

Further, both MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, and NBQX, an alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)/kainate (KA) receptor antagonist, attenuated deltamethrin-elicited prolonged expression of c-Fos and c-Jun.
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11416227 Li WI, Berman FW, Okino T, Yokokawa F, Shioiri T, Gerwick WH, Murray TF: Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7599-604.

ATX is neurotoxic in primary cultures of rat cerebellar granule cells, and this neuronal death is prevented by either N-methyl-d-aspartate (NMDA) receptor antagonists or tetrodotoxin.
Positive allosteric interactions were not observed between ATX and either alpha-scorpion toxin or the pyrethroid deltamethrin.
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10807662 Wirkner K, Assmann H, Koles L, Gerevich Z, Franke H, Norenberg W, Boehm R, Illes P: Inhibition by adenosine A (2A) receptors of NMDA but not AMPA currents in rat neostriatal neurons. Br J Pharmacol. 2000 May;130(2):259-69.

The calcineurin inhibitor deltamethrin did not interfere with CGS 21680.
It is suggested that the transduction mechanism of A (2A) receptors to inhibit NMDA receptor channels is the phospholipase C/InsP (3)/calmodulin and calmodulin kinase II pathway.
1(0,0,0,1) Details