| Name | protein phosphatase |
|---|---|
| Synonyms | DUSP17; DUSP19; Dual specificity phosphatase 19; Dual specificity protein phosphatase 19; Dual specificity phosphatase TS DSP1; LMW DSP3; Protein phosphatase; Protein phosphatase SKRP1… |
| Name | deltamethrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15337272 | Choi JS, Soderlund DM: Cyclosporin A and deltamethrin block the downregulation of Nav1.8 channels expressed in Xenopus oocytes. Neurosci Lett. 2004 Sep 9;367(3):389-93. Perfusion of oocytes with either cyclosporin A or deltamethrin, considered to be diagnostic inhibitors of the protein phosphatase calcineurin, at 10 microM blocked spontaneous downregulation. |
81(1,1,1,1) | Details |
| 10995774 | Hoy M, Bokvist K, Xiao-Gang W, Hansen J, Juhl K, Berggren PO, Buschard K, Gromada J: Phentolamine inhibits exocytosis of glucagon by Gi2 protein-dependent activation of calcineurin in rat pancreatic alpha -cells. J Biol Chem. 2001 Jan 12;276(2):924-30. The inhibitory effect of phentolamine on exocytosis resulted from activation of the protein phosphatase calcineurin and was abolished by cyclosporin A and deltamethrin. |
31(0,1,1,1) | Details |
| 17200551 | Swingle M, Ni L, Honkanen RE: Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse. Methods Mol Biol. 2007;365:23-38. Inhibitors of PP2B (calcineurin) will only be mentioned in passing, except to state that, in our hands, cypermethrin, deltamethrin, and fenvalerate, which are sold as potent inhibitors of PP2B, do not inhibit the catalytic activity of PP2B. |
2(0,0,0,2) | Details |
| 8985861 | Hardwick JC, Parsons RL: Activation of the protein phosphatase calcineurin during carbachol exposure decreases the extent of recovery from end-plate desensitization. J Neurophysiol. 1996 Dec;76(6):3609-16. This staurosporine-induced decrease in sensitivity could be prevented by pretreatment with the protein phosphatase 2B (calcineurin) inhibitor deltamethrin (0.5 microM), whereas okadaic acid (5 microM) and calyculin A (0.5 microM), inhibitors of protein phosphatases 1 and 2A, had no effect. 3. |
2(0,0,0,2) | Details |
| 10781439 | Taylor BK, Stoops TD, Everett AD: Protein phosphatase inhibitors arrest cell cycle and reduce branching morphogenesis in fetal rat lung cultures. Am J Physiol Lung Cell Mol Physiol. 2000 May;278(5):L1062-70. Microdissected lung primordia were cultured in medium containing one of either two PP2A inhibitors, okadaic acid (OA, 0-9 nM) or cantharidin (Can, 0-3,600 nM), or with the PP2B inhibitor deltamethrin (Del, 0-10 microM) as a control for a PP2A-specific effect for 48 h. |
2(0,0,0,2) | Details |
| 1315545 | Enan E, Matsumura F: Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides. Biochem Pharmacol. 1992 Apr 15;43(8):1777-84. The inhibitory action of synthetic pyrethroids and some chlorinated hydrocarbon insecticides on the neural -calmodulin-dependent protein phosphatase, calcineurin, was studied using one radiotracer and two colorimetric methods. It was found that all insecticidal Type II pyrethroids (cypermethrin, deltamethrin and fenvalerate) are potent inhibitors of isolated calcineurin from bovine brain. |
1(0,0,0,1) | Details |
| 12242407 | Allen GJ, Sanders D: Calcineurin, a Type 2B Protein Phosphatase, Modulates the Ca2+-Permeable Slow Vacuolar Ion Channel of Stomatal Guard Cells. Plant Cell. 1995 Sep;7(9):1473-1483. The inhibitory effect of calcineurin could be blocked by the pyrethroid deltamethrin, indicating inhibition of SV channels by calcineurin via dephosphorylation. |
1(0,0,0,1) | Details |
| 8661777 | Vayro S, Simmons NL: An effect of Ca2+ on the Intrinsic Cl (-)-conductance of rat kidney cortex brush border membrane vesicles. J Membr Biol. 1996 Mar;150(2):163-73. In addition, inhibitors of protein phosphatase 2B, deltamethrin (50 nM) and trifluoperazine (10 microM), caused partial reversal of Ca2 (+)-dependent inhibition of uptake. |
0(0,0,0,0) | Details |
| 15579596 | Ashizawa K, Wishart GJ, Ranasinghe AR, Katayama S, Tsuzuki Y: Protein phosphatase-type 2B is involved in the regulation of the acrosome reaction but not in the temperature-dependent flagellar movement of fowl spermatozoa. Reproduction. 2004 Dec;128(6):783-7. The presence of deltamethrin or fenvalerate, specific inhibitors of protein phosphatase-type 2B (PP2B), did not permit the restoration of motility at 40 degrees C but, in the presence of IPVL, these compounds stimulated the acrosome reaction in a dose-dependent manner in the range of 1-1000 nmol/l. |
0(0,0,0,0) | Details |
| 8866865 | Godart H, Ellory JC: KCl cotransport activation in human erythrocytes by high hydrostatic pressure. J Physiol. 1996 Mar 1;491 ( Pt 2):423-34. In contrast, deltamethrin, a specific protein phosphatase type 2B inhibitor, did not affect the stimulation by pressure, up to a concentration of 10 microM. 5. |
0(0,0,0,0) | Details |
| 17171635 | Rajgopal A, Young DW, Mujeeb KA, Stein JL, Lian JB, van Wijnen AJ, Stein GS: Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells. J Cell Biochem. 2007 Apr 15;100(6):1509-17. This conversion is inhibited by okadaic acid, an inhibitor of protein phosphatases 1 and 2 (PP1 and PP2A), but not by deltamethrin which blocks PP2B phosphatase. |
0(0,0,0,0) | Details |
| 10936494 | Thompson TL, Moore CC, Smith B: priming modulates autoreceptor-mediated potentiation of uptake. Eur J Pharmacol. 2000 Aug 11;401(3):357-63. The ability of selective protein phosphatase inhibitors to modulate autoreceptor-mediated potentiation of uptake was also examined. Pretreatment with protein phosphatase 2B (deltamethrin, cypermethrin) or protein phosphatase 1 (tautomycin) inhibitors attenuated basal and quinpirole-potentiated uptake in ovariectomized but not -primed tissue. |
1(0,0,0,1) | Details |