Protein Information

Name tyrosine hydroxylase
Synonyms Putative tyrosine hydroxylase variant; TH; TH protein; TYH; Truncated tyrosine hydroxylase; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyrosine hydroxylase…

Compound Information

Name deltamethrin
CAS

Reference List

PubMed Abstract RScore(About this table)
16673815 Liu GP, Ma Q, Shi N: Tyrosine hydroxylase as a target for deltamethrin in the nigrostriatal dopaminergic pathway. Biomed Environ Sci. 2006 Feb;19(1):27-34.
120(1,2,3,5) Details
16229977 Liu GP, Shi N: The inhibitory effects of deltamethrin on dopamine biosynthesis in rat PC12 cells. Toxicol Lett. 2006 Mar 1;161(3):195-9. Epub 2005 Oct 17.

Flow cytometry (FCM) and RT-PCR technology were used to detect the levels of tyrosine hydroxylase (TH) mRNA and protein in PC12 cells treated with different doses of deltamethrin for 3 h or 12 h.
12(0,0,2,2) Details
15461254 Liu G, Shi N, Ma R: [Effects of pyrethroids on tyrosine hydroxylase in nigrostriatum of male rats]. Wei Sheng Yan Jiu. 2004 Jul;33(4):390-3.

METHODS: Different doses of permethrin and deltamethrin in corn oil were administered to rats by gavage for ten days, then PLC-Fluorescence detection was used to analyzed the contents of dopamine (DA), DOPAC and HVA in the Substantial Nigra and Striatum.
4(0,0,0,4) Details
15555315 Liu GP, Shi N, Liang JH, Chen L: [Effects of pyrethroids on dopamine and its metabolites in nigrostriatum of male rats.]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Oct;22(5):368-70.

METHODS: Different doses of permethrin (PM, 200, 400 mg/kg) and deltamethrin (DM, 6.25, 12.50 mg/kg) in corn oil were administered to rats by gavage once daily for ten days, then the contents of dopamine (DA) and its metabolites, 3, 4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the substantial nigra and striatum were analyzed by HPLC-fluorescence detection.
CONCLUSION: DM may inhibit tyrosine hydroxylase and decrease the level of DA in striatum, and both pyrethroid pesticides may increase the metabolism of dopamine in striatum.
1(0,0,0,1) Details