Protein Information

Name somatostatin
Synonyms Growth hormone release inhibiting factor; SMST; SST; Somatostatin; Somatostatin precursor; Somatostatins; Somatostatin precursors

Compound Information

Name deltamethrin
CAS

Reference List

PubMed Abstract RScore(About this table)
11533141 Gromada J, Hoy M, Buschard K, Salehi A, Rorsman P: Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G (i2)-dependent activation of calcineurin and depriming of secretory granules. J Physiol. 2001 Sep 1;535(Pt 2):519-32.

The inhibitory effect of somatostatin on exocytosis was mediated by activation of the serine/threonine protein phosphatase calcineurin and was prevented by pretreatment with cyclosporin A and deltamethrin or intracellularly applied calcineurin autoinhibitory peptide.
89(1,1,1,9) Details
12044486 Grosse G, Thiele T, Heuckendorf E, Schopp E, Merder S, Pickert G, Ahnert-Hilger G: Deltamethrin differentially affects neuronal subtypes in hippocampal primary culture. Neuroscience. 2002;112(1):233-41.

When analyzing subtypes of neurons calbindin- as well as somatostatin-positive neurons decreased by 50% after repeated treatment with 2 nM deltamethrin.
6(0,0,1,1) Details
10844399 Kampermann J, Herbst M, Ullrich S: Effects of adrenaline and tolbutamide on insulin secretion in INS-1 cells under voltage control. Cell Physiol Biochem. 2000;10(1-2):81-90.

After incubation of the cells with deltamethrin, a calcineurin inhibitor, the stimulation of secretion was attenuated, but the adrenaline-induced inhibition was not affected.
The aim of the present study was to investigate whether mechanisms distal to the regulation of Ca2-influx are involved in tolbutamide-induced stimulation and adrenaline- and somatostatin- induced inhibition of insulin secretion in INS-1 cells.
2(0,0,0,2) Details