| 18983829 |
Yang D, Pearce RE, Wang X, Gaedigk R, Wan YJ, Yan B: Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin. Biochem Pharmacol. 2009 Jan 15;77(2):238-47. Epub 2008 Oct 15.
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8(0,0,1,3) |
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| 16855054 |
Godin SJ, Scollon EJ, Hughes MF, Potter PM, DeVito MJ, Ross MK: Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats. Drug Metab Dispos. 2006 Oct;34(10):1764-71. Epub 2006 Jul 19.
Results of CE metabolism revealed that human carboxylesterase 1 (hCE-1) was markedly more active toward deltamethrin than the class 1 rat CEs hydrolase A and B and the class 2 human CE (hCE-2); however, hydrolase A metabolized esfenvalerate 2-fold faster than hCE-1, whereas hydrolase B and hCE-1 hydrolyzed esfenvalerate at equal rates. |
81(1,1,1,1) |
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