Protein Information

Name G6PD
Synonyms G6PD; G6PD1; G6PDH; Glucose 6 phosphate 1 dehydrogenase; Glucose 6 phosphate dehydrogenase; NADP oxidoreductase; glucose 6 phosphate; Glucose 6 phosphate 1 dehydrogenases…

Compound Information

Name deltamethrin
CAS

Reference List

PubMed Abstract RScore(About this table)
1678732 Kumar S, Thomas A, Pillai MK: Involvement of mono-oxygenases as a major mechanism of deltamethrin-resistance in larvae of three species of mosquitoes. Indian J Exp Biol. 1991 Apr;29(4):379-84.

In addition, the activity of glucose-6-phosphate dehydrogenase (G6PD), the main NADPH generating enzyme for mono-oxygenases, also showed enhanced activity in deltamethrin and DDT-selected strains.
7(0,0,1,2) Details
19225809 Jagadeshwaran U, Vijayan VA: Biochemical characterization of deltamethrin resistance in a laboratory-selected strain of Aedes aegypti. Parasitol Res. 2009 Jun;104(6):1431-8. Epub 2009 Feb 19.

Significant elevation in the activity of alpha- and beta-esterases, glucose-6-phosphate dehydrogenase (G6PD), CYTP450 (CYTP450), and glutathione-s-transferase (GST) were noticed in DR.
2(0,0,0,2) Details
12622206 Ganesh KN, Vijayan VA, Urmila J, Gopalan N, Prakash S: Role of esterases and monooxygenase in the deltamethrin resistance in Anopheles stephensi Giles (1908), at Mysore. Indian J Exp Biol. 2002 May;40(5):583-8.

The reason for this kind of resistance was analyzed on the basis of differential activity of A-esterase, B-esterase, glutathione s-transferase (GST) and glucose 6-phosphate dehydrogenase (G6PD).
2(0,0,0,2) Details
8435483 Mourya DT, Hemingway J, Leake CJ: Changes in enzyme titres with age in four geographical strains of Aedes aegypti and their association with insecticide resistance. Med Vet Entomol. 1993 Jan;7(1):11-6.

The combination of DDT and deltamethrin resistance in two strains with normal GST and G6PD characteristics suggests that a kdr-type nerve insensitivity mechanism may be involved.
33(0,1,1,3) Details
12866824 Ganesh KN, Urmila J, Vijayan VA: Pyrethroid susceptibility & enzyme activity in two malaria vectors, Anopheles stephensi (Liston) &. Indian J Med Res. 2003 Jan;117:30-8.

Thus, A. stephensi was found to be tolerant to deltamethrin depicting a higher activity of A-esterase and GST enzymes, whereas the higher activity of B-esterase and G6PD has resulted in the development of tolerance to permethrin in A. culicifacies.
8(0,0,1,3) Details
11802603 Kamalaveni K, Gopal V, Sampson U, Aruna D: Effect of pyrethroids on carbohydrate metabolic pathways in common carp, Cyprinus carpio. Pest Manag Sci. 2001 Dec;57(12):1151-4.

The activity levels of succinate dehydrogenase (SDH) and glucose-6-phosphate dehydrogenase (G6PD) were assessed in various tissues of Cyprinus carpio var communis which had been exposed to lethal concentrations of group-II pyrethroids (deltamethrin, cypermethrin, fenvalerate and fluvalinate) for a period of 72 h.
8(0,0,1,3) Details