Protein Information

Name Nav1.4
Synonyms HYKPP; HYPP; NAC1A; Na(V)1.4; Nav1.4; SCN4A; SkM1; Sodium channel protein type 4 subunit alpha…

Compound Information

Name deltamethrin
CAS

Reference List

PubMed Abstract RScore(About this table)
11502895 Wang SY, Barile M, Wang GK: A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na (+) channels is critical for pyrethroid action. Mol Pharmacol. 2001 Sep;60(3):620-8.

A background mutation, Nav1.4-I687M (within D2:S4-S5 cytoplasmic linker), enhanced the deltamethrin-induced maintained current by approximately 2.5-fold, whereas Nav1.4-I687T, a homologous superkdr mutation, reduced it by approximately 2-fold.
56(0,1,5,6) Details