Protein Information

Name PP2A
Synonyms PP2A; PP2A subunit B prime; PR53; PTPA; Phosphotyrosyl phosphatase activator; Serine/threonine protein phosphatase 2A regulatory subunit B'; PP2A subunit B primes…

Compound Information

Name deltamethrin
CAS

Reference List

PubMed Abstract RScore(About this table)
17171635 Rajgopal A, Young DW, Mujeeb KA, Stein JL, Lian JB, van Wijnen AJ, Stein GS: Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells. J Cell Biochem. 2007 Apr 15;100(6):1509-17.

This conversion is inhibited by okadaic acid, an inhibitor of protein phosphatases 1 and 2 (PP1 and PP2A), but not by deltamethrin which blocks PP2B phosphatase.
2(0,0,0,2) Details
10781439 Taylor BK, Stoops TD, Everett AD: Protein phosphatase inhibitors arrest cell cycle and reduce branching morphogenesis in fetal rat lung cultures. Am J Physiol Lung Cell Mol Physiol. 2000 May;278(5):L1062-70.

Microdissected lung primordia were cultured in medium containing one of either two PP2A inhibitors, okadaic acid (OA, 0-9 nM) or cantharidin (Can, 0-3,600 nM), or with the PP2B inhibitor deltamethrin (Del, 0-10 microM) as a control for a PP2A-specific effect for 48 h.
38(0,1,1,8) Details
17200551 Swingle M, Ni L, Honkanen RE: Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse. Methods Mol Biol. 2007;365:23-38.

Common mistakes in the employment of these compounds will also be addressed briefly, notably the widespread misconception that they only inhibit the activity of PP1 and PP2A.
Inhibitors of PP2B (calcineurin) will only be mentioned in passing, except to state that, in our hands, cypermethrin, deltamethrin, and fenvalerate, which are sold as potent inhibitors of PP2B, do not inhibit the catalytic activity of PP2B.
1(0,0,0,1) Details