| Name | calcineurin (protein family or complex) |
|---|---|
| Synonyms | Calcineurin; Calcineurins; Protein phosphatase 2B |
| Name | deltamethrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1315545 | Enan E, Matsumura F: Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides. Biochem Pharmacol. 1992 Apr 15;43(8):1777-84. It was found that all insecticidal Type II pyrethroids (cypermethrin, deltamethrin and fenvalerate) are potent inhibitors of isolated calcineurin from bovine brain. |
85(1,1,1,5) | Details |
| 12242407 | Allen GJ, Sanders D: Calcineurin, a Type 2B Protein Phosphatase, Modulates the Ca2+-Permeable Slow Vacuolar Ion Channel of Stomatal Guard Cells. Plant Cell. 1995 Sep;7(9):1473-1483. The inhibitory effect of calcineurin could be blocked by the pyrethroid deltamethrin, indicating inhibition of SV channels by calcineurin via dephosphorylation. |
84(1,1,1,4) | Details |
| 17551263 | Martin C, Jacobi JS, Nava G, Jeziorski MC, Clapp C, Martinez de la Escalera G: inhibition of cyclic AMP production in immortalized GnRH neurons is mediated by calcineurin-dependent dephosphorylation of adenylyl cyclase 9. Neuroendocrinology. 2007;85(4):257-66. Epub 2007 Jun 4. Furthermore, blocking calcineurin with deltamethrin, FK-506 or cyclosporin A blocked the inhibitory effect of on [cAMP] i, supporting the involvement of AC9 in this effect. |
83(1,1,1,3) | Details |
| 16678970 | Wu ZZ, Chen SR, Pan HL: Signaling mechanisms of down-regulation of voltage-activated Ca2+ channels by transient receptor potential vanilloid type 1 stimulation with olvanil in primary sensory neurons. Neuroscience. 2006 Aug 11;141(1):407-19. Epub 2006 May 6. Furthermore, calcineurin (protein phosphatase 2B) inhibitors (deltamethrin and FK-506) eliminated the effect of olvanil on voltage-activated Ca (2+) channel current. |
82(1,1,1,2) | Details |
| 9379408 | Traynelis SF, Wahl P: Control of rat GluR6 glutamate receptor open probability by protein kinase A and calcineurin. J Physiol. 1997 Sep 15;503 ( Pt 3):513-31. The calcineurin-stimulated decrease of Po,peak in cells co-transfected with C alpha-PKA is blocked by 800 nM deltamethrin, a calcineurin inhibitor. |
36(0,1,1,6) | Details |
| 15337272 | Choi JS, Soderlund DM: Cyclosporin A and deltamethrin block the downregulation of Nav1.8 channels expressed in Xenopus oocytes. Neurosci Lett. 2004 Sep 9;367(3):389-93. Perfusion of oocytes with either cyclosporin A or deltamethrin, considered to be diagnostic inhibitors of the protein phosphatase calcineurin, at 10 microM blocked spontaneous downregulation. |
82(1,1,1,2) | Details |
| 9714322 | Fakata KL, Swanson SA, Vorce RL, Stemmer PM: Pyrethroid insecticides as phosphatase inhibitors. . Biochem Pharmacol. 1998 Jun 15;55(12):2017-22. The type II pyrethroid insecticides cis-cypermethrin (c-Cyp), trans-cypermethrin, deltamethrin (Delt), and fenvalerate A alpha (Fen), as well as the type I pyrethroid insecticides cis- and trans-permethrin and S-bioallethrin, were unable to inhibit the phosphatase activity of purified calcineurin under conditions of maximal activation by Ca2+ and calmodulin. |
82(1,1,1,2) | Details |
| 10794729 | Bandyopadhyay A, Shin DW, Kim DH: Regulation of ATP-induced release in COS-7 cells by calcineurin. . Biochem J. 2000 May 15;348 Pt 1:173-81. Measurement of calcineurin-specific phosphatase activity in vitro demonstrated a high level of endogenous calcineurin activities in COS-7 cells, which was effectively inhibited by the addition of deltamethrin or CsA. |
39(0,1,1,9) | Details |
| 10995774 | Hoy M, Bokvist K, Xiao-Gang W, Hansen J, Juhl K, Berggren PO, Buschard K, Gromada J: Phentolamine inhibits exocytosis of glucagon by Gi2 protein-dependent activation of calcineurin in rat pancreatic alpha -cells. J Biol Chem. 2001 Jan 12;276(2):924-30. The inhibitory effect of phentolamine on exocytosis resulted from activation of the protein phosphatase calcineurin and was abolished by cyclosporin A and deltamethrin. |
33(0,1,1,3) | Details |
| 11533141 | Gromada J, Hoy M, Buschard K, Salehi A, Rorsman P: Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G (i2)-dependent activation of calcineurin and depriming of secretory granules. J Physiol. 2001 Sep 1;535(Pt 2):519-32. The inhibitory effect of somatostatin on exocytosis was mediated by activation of the serine/threonine protein phosphatase calcineurin and was prevented by pretreatment with cyclosporin A and deltamethrin or intracellularly applied calcineurin autoinhibitory peptide. |
33(0,1,1,3) | Details |
| 7531976 | Richter A, Davies DE, Alexander P: Growth inhibitory effects of FK506 and cyclosporin A independent of inhibition of calcineurin. Biochem Pharmacol. 1995 Jan 31;49(3):367-73. The role of calcineurin in CyA- or FK506-induced growth inhibition was investigated using the synthetic pyrethroid insecticides: cypermethrin, deltamethrin and fenvalerate, which are known calcineurin inhibitors. |
32(0,1,1,2) | Details |
| 10575025 | Liu Q, Berg DK: Actin filaments and the opposing actions of CaM kinase II and calcineurin in regulating alpha7-containing nicotinic receptors on chick ciliary ganglion neurons. J Neurosci. 1999 Dec 1;19(23):10280-8. Blockade of calmodulin by calmidazolium or blockade of CaM kinase II with either KN93 or autocamtide-2-related inhibitory peptide each prevents the rundown; blockade of the phosphatase calcineurin with either cyclosporin A or deltamethrin increases the rundown. |
32(0,1,1,2) | Details |
| 8661777 | Vayro S, Simmons NL: An effect of Ca2+ on the Intrinsic Cl (-)-conductance of rat kidney cortex brush border membrane vesicles. J Membr Biol. 1996 Mar;150(2):163-73. In addition, inhibitors of protein phosphatase 2B, deltamethrin (50 nM) and trifluoperazine (10 microM), caused partial reversal of Ca2 (+)-dependent inhibition of uptake. |
31(0,1,1,1) | Details |
| 10535451 | Poulsen CR, Bokvist K, Olsen HL, Hoy M, Capito K, Gilon P, Gromada J: Multiple sites of purinergic control of insulin secretion in mouse pancreatic beta-cells. Diabetes. 1999 Nov;48(11):2171-81. Inhibition of exocytosis by ATP resulted from G-protein-dependent activation of the serine/threonine protein phosphatase calcineurin and was abolished by cyclosporin A and deltamethrin. |
31(0,1,1,1) | Details |
| 18611438 | Ranta F, Dufer M, Stork B, Wesselborg S, Drews G, Haring HU, Lang F, Ullrich S: Regulation of calcineurin activity in insulin-secreting cells: stimulation by Hsp90 during glucocorticoid-induced apoptosis. Cell Signal. 2008 Oct;20(10):1780-6. Epub 2008 Jun 18. Previously, we described that apoptotic cell death induced by the synthetic glucocorticoid dexamethasone (dex) is inhibited by calcineurin inhibitors, FK506 and deltamethrin, in insulin-secreting cells. |
6(0,0,0,6) | Details |
| 11062058 | Bandyopadhyay A, Shin DW, Ahn JO, Kim DH: Calcineurin regulates ryanodine receptor/Ca (2+)-release channels in rat heart. Biochem J. 2000 Nov 15;352 Pt 1:61-70. Treatment of neonatal cardiomyocytes with 20 microM deltamethrin, 10 microM cyclosporin A (CsA), or 10 mciroM FK506 led to Ca (2+) oscillations in originally quiescent cardiomyocytes. |
6(0,0,0,6) | Details |
| 9572286 | Matsuda T, Takuma K, Asano S, Kishida Y, Nakamura H, Mori K, Maeda S, Baba A: Involvement of calcineurin in Ca2+ paradox-like injury of cultured rat astrocytes. J Neurochem. 1998 May;70(5):2004-11. Deltamethrin (20 nM), another calcineurin inhibitor, had a similar protective effect, whereas okadaic acid did not. |
6(0,0,0,6) | Details |
| 8985861 | Hardwick JC, Parsons RL: Activation of the protein phosphatase calcineurin during carbachol exposure decreases the extent of recovery from end-plate desensitization. J Neurophysiol. 1996 Dec;76(6):3609-16. This staurosporine-induced decrease in sensitivity could be prevented by pretreatment with the protein phosphatase 2B (calcineurin) inhibitor deltamethrin (0.5 microM), whereas okadaic acid (5 microM) and calyculin A (0.5 microM), inhibitors of protein phosphatases 1 and 2A, had no effect. 3. |
3(0,0,0,3) | Details |
| 9539223 | Amico C, Cupello A, Fossati C, Robello M: Involvement of phosphatase activities in the run-down of (A) receptor function in rat cerebellar granule cells in culture. Neuroscience. 1998 May;84(2):529-35. This event could be prevented, even in the absence of ATP, by using the perforated-patch technique or by adding to the pipette medium either a blocker of protein tyrosine phosphatase, vanadate, or deltamethrin, a blocker of the protein serine/ phosphatase calcineurin. This event could be prevented, even in the absence of ATP, by using the perforated-patch technique or by adding to the pipette medium either a blocker of protein tyrosine phosphatase, vanadate, or deltamethrin, a blocker of the protein serine/ phosphatase calcineurin. |
1(0,0,0,1) | Details |
| 9037753 | Robello M, Amico C, Cupello A: A dual mechanism for impairment of GABAA receptor activity by NMDA receptor activation in rat cerebellum granule cells. Eur Biophys J. 1997;25(3):181-7. On the one hand Ca+2 influx across channels activates calcineurin and dephosphorylates the GABAA receptor complex directly or dephosphorylates proteins critical for the function of the receptor. The effect was reduced by including -5'-O-3-thiophosphate (ATP-gamma-S) in the internal solution and there was a reduction in the effect caused by deltamethrin, a calcineurin inhibitor. |
1(0,0,0,1) | Details |
| 8948591 | Carrera A, Moos J, Ning XP, Gerton GL, Tesarik J, Kopf GS, Moss SB: Regulation of protein phosphorylation in human sperm by a /calmodulin-dependent mechanism: identification of A kinase anchor proteins as major substrates for phosphorylation. Dev Biol. 1996 Nov 25;180(1):284-96. This Ca2+-induced dephosphorylation was calmodulin-dependent, suggesting that calcineurin was involved. In this regard, the calcineurin inhibitor deltamethrin inhibited the Ca2+ ionophore-induced dephosphorylation. |
1(0,0,0,1) | Details |
| 10627609 | Lautermilch NJ, Spitzer NC: Regulation of calcineurin by growth cone waves controls neurite extension. J Neurosci. 2000 Jan 1;20(1):315-25. Pharmacological blockers of CN (cyclosporin A and deltamethrin) and peptide inhibitors of CN [the Xenopus CN (xCN) autoinhibitory domain and African swine fever virus protein A238L] block the Ca (2+)-dependent reduction of neurite outgrowth in cultured neurons. |
2(0,0,0,2) | Details |
| 16644695 | Ranta F, Avram D, Berchtold S, Dufer M, Drews G, Lang F, Ullrich S: Dexamethasone induces cell death in insulin-secreting cells, an effect reversed by exendin-4. Diabetes. 2006 May;55(5):1380-90. Dexamethasone increased PP-2B (calcineurin) activity, an effect abrogated by FK506. FK506 (0.1 micromol/l) and another calcineurin inhibitor, deltamethrin (1 micromol/l), attenuated dexamethasone-induced cell death. |
2(0,0,0,2) | Details |
| 9594016 | Fischer H, Illek B, Machen TE: Regulation of CFTR by protein phosphatase 2B and protein kinase C. . Pflugers Arch. 1998 Jul;436(2):175-81. Treating CFTR-expressing 3T3 cells with either of the two specific PP2B blockers cyclosporin A (CsA, 1 microM) or deltamethrin (DM, 30 nM) caused rapid activation of CFTR in cell-attached patches. |
2(0,0,0,2) | Details |
| 15746091 | Wu ZZ, Chen SR, Pan HL: Transient receptor potential vanilloid type 1 activation down-regulates voltage-gated channels through -dependent calcineurin in sensory neurons. J Biol Chem. 2005 May 6;280(18):18142-51. Epub 2005 Mar 3. Furthermore, intracellular dialysis of deltamethrin or cyclosporin A, the specific calcineurin (protein phosphatase 2B) inhibitors, but not okadaic acid (a selective protein phosphatase 1/protein phosphatase 2A inhibitor), abolished the effect of on I (Ca). |
2(0,0,0,2) | Details |
| 10844399 | Kampermann J, Herbst M, Ullrich S: Effects of and on insulin secretion in INS-1 cells under voltage control. Cell Physiol Biochem. 2000;10(1-2):81-90. After incubation of the cells with deltamethrin, a calcineurin inhibitor, the stimulation of secretion was attenuated, but the -induced inhibition was not affected. |
0(0,0,0,0) | Details |
| 17200551 | Swingle M, Ni L, Honkanen RE: Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse. Methods Mol Biol. 2007;365:23-38. Inhibitors of PP2B (calcineurin) will only be mentioned in passing, except to state that, in our hands, cypermethrin, deltamethrin, and fenvalerate, which are sold as potent inhibitors of PP2B, do not inhibit the catalytic activity of PP2B. |
0(0,0,0,0) | Details |
| 11562451 | Dufer M, Krippeit-Drews P, Lembert N, Idahl LA, Drews G: Diabetogenic effect of cyclosporin A is mediated by interference with mitochondrial function of pancreatic B-cells. Mol Pharmacol. 2001 Oct;60(4):873-9. This effect is not due to an inhibition of calcineurin, which mediates the immunosuppressive effect of CsA, because other calcineurin inhibitors, deltamethrin and tacrolimus, did not affect the oscillations in [Ca (2+)](c) of the B-cells. |
0(0,0,0,0) | Details |
| 10936494 | Thompson TL, Moore CC, Smith B: priming modulates autoreceptor-mediated potentiation of uptake. Eur J Pharmacol. 2000 Aug 11;401(3):357-63. Pretreatment with protein phosphatase 2B (deltamethrin, cypermethrin) or protein phosphatase 1 (tautomycin) inhibitors attenuated basal and quinpirole-potentiated uptake in ovariectomized but not -primed tissue. |
0(0,0,0,0) | Details |