Protein Information

Name angiotensin I
Synonyms AGT; ANG II; ANHU; Angiotensin I; Angiotensin II; Angiotensinogen; Angiotensinogen precursor; SERPINA 8…

Compound Information

Name antu
CAS 1-naphthalenylthiourea

Reference List

PubMed Abstract RScore(About this table)
2995022 O'Brien RF, Makarski JS, Rounds S: Studies on the mechanism of decreased angiotensin I conversion in rat lungs injured with alpha-naphthylthiourea. Exp Lung Res. 1985;8(4):243-59.

We conclude that angiotensin I conversion is decreased after ANTU lung injury and that the extent of decrease is related to the dose of ANTU and to perfusate flow rate.
113(1,2,2,3) Details
3930163 Rounds S, Farber HW, Hill NS, O'Brien RF: Effects of endothelial cell injury on pulmonary vascular reactivity. Chest. 1985 Oct;88(4 Suppl):213S-216S.

Using the thiocarbamide model of acute lung injury in rats, we found that alpha-naphthylthiourea (ANTU) caused lung endothelial cell injury, as evidenced by increased permeability edema and decreased angiotensin I conversion.
31(0,1,1,1) Details
6231274 Hill NS, O'Brien RF, Rounds S: Repeated lung injury due to alpha-naphthylthiourea causes right ventricular hypertrophy in rats. J Appl Physiol. 1984 Feb;56(2):388-96.

Lungs isolated from ANTU-injected rats had greater pressor responses to hypoxia and to angiotensin II than lungs from Tween 80-injected rats.
6(0,0,1,1) Details
3004269 Feddersen CO, McMurtry IF, Henson P, Voelkel NF: Acetylcholine-induced pulmonary vasodilation in lung vascular injury. Am Rev Respir Dis. 1986 Feb;133(2):197-204.


We therefore induced pulmonary endothelial cell injury in one rat model by repeated injections of alpha-naphthyl thiourea (ANTU) and in a second rat model by exposing rats for 52 h to 100% oxygen at a barometric pressure of 760 torr (hyperoxia).
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6409860 Hill NS, Rounds S: Vascular reactivity is increased in rat lungs injured with alpha-naphthylthiourea. J Appl Physiol. 1983 Jun;54(6):1693-701.


We investigated the effects of lung injury due to alpha-naphthylthiourea (ANTU) on pulmonary vascular reactivity.
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8971961 Sipahi E, Hodoglugil U, Ercan ZS, Turker RK: Acute effect of endothelin-1 on lung oedema induced by alpha-naphthylthiourea (ANTU). Pharmacol Res. 1996 Jun;33(6):375-8.

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