Protein Information

Name monoamine oxidase
Synonyms Adrenalin oxidase; Amine oxidase; Amine oxidase [flavin containing] B; MAO B; MAOB; Monoamine oxidase; Monoamine oxidase B; Monoamine oxidase type B…

Compound Information

Name sodium cyanide
CAS sodium cyanide (Na(CN))

Reference List

PubMed Abstract RScore(About this table)
10092944 Zajoncova L, Frebort I, Luhova L, Sebela M, Galuszka P, Pec P: Comparison of kinetic properties of amine oxidases from sainfoin and lentil and immunochemical characterization of copper/quinoprotein amine oxidases. Biochem Mol Biol Int. 1999 Jan;47(1):47-61.

Both amine oxidases, like other plant Cu-amine oxidases, were inhibited by substrate analogs (1,5-diamino-3-pentanone, 1,4-diamino-2-butanone and aminoguanidine), Cu2+ chelating agents (diethyltriamine, 1,10-phenanthroline, 8-hydroxyquinoline, 2,2'-bipyridyl, imidazole, sodium cyanide and sodium azide), some alkaloids (L-lobeline and cinchonine), some lathyrogens (beta-aminopropionitrile and aminoacetonitrile) and other inhibitors (benzamide oxime, acetone oxime, hydroxylamine and pargyline).
33(0,1,1,3) Details
8117318 Cassel GE, Persson SA, Stenstrom A: Effects of cyanide in vitro on the activity of monoamine oxidase in striatal tissue from rat and pig. Biochem Pharmacol. 1994 Feb 9;47(3):499-504.

In order to elucidate further these findings we examined the effects in vitro of sodium cyanide on rat and pig brain monoamine oxidase (MAO; EC 1.4.3.4).
7(0,0,1,2) Details
3876442 Peterson LA, Caldera PS, Trevor A, Chiba K, Castagnoli N Jr: Studies on the 1-methyl-4-phenyl-2,3-dihydropyridinium species 2,3-MPDP+, the monoamine oxidase catalyzed oxidation product of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). J Med Chem. 1985 Oct;28(10):1432-6.

Results presented in this paper confirm the first assignment and establish that, although the proposed 6-cyano adduct is initially formed, the product that was isolated from the mitochondrial incubation mixtures of MPTP and sodium cyanide actually is the isomeric 2-cyano-1-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine.
2(0,0,0,2) Details
1762989 Abrahamsen J: Accumulation and release of adrenaline, and the modulation by adrenaline of noradrenaline release from rabbit blood vessels in vitro. Pharmacol Toxicol. 1991;69 Suppl 3:1-40.

Ouabain and iodoacetic acid, but not sodium cyanide and 2,4-dinitrophenol, reduced the accumulation of 3H derived from 3H-A.
In all experiments, monoamine oxidase and catechol-O-methyltransferase were inhibited by treatment with pargyline and 3',4'-dihydroxy-2-methyl-propiophenone, respectively.
1(0,0,0,1) Details
2861994 Chiba K, Peterson LA, Castagnoli KP, Trevor AJ, Castagnoli N Jr: Studies on the molecular mechanism of bioactivation of the selective nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Drug Metab Dispos. 1985 May-Jun;13(3):342-7.

Detailed studies have been carried out on the monoamine oxidase B-catalyzed bioactivation of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by rat brain mitochondrial preparations.
Further characterization of MPDP+ was achieved by comparison of the diode array UV spectral tracings of the metabolite with synthetic MPDP+ perchlorate (CIO4-) and by the isolation of a cyano adduct from mitochondrial coincubation mixtures of MPTP and sodium cyanide.
1(0,0,0,1) Details