| Name | CYP2E1 |
|---|---|
| Synonyms | CPE 1; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CPE1; CYP2E; CYP2E1; CYP2E1 protein… |
| Name | piperonyl butoxide |
|---|---|
| CAS | 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12593759 | Pass GJ, McLean S: Inhibition of the microsomal metabolism of in the common brushtail possum (Trichosurus vulpecula) by terpenes and other chemicals. Xenobiotica. 2002 Dec;32(12):1109-26. Diethyldithiocarbamate also inhibited 9-hydroxylation in the possum, indicating that a CYP2E1-like enzyme contributes to this reaction. 3. |
1(0,0,0,1) | Details |
| 8887459 | Zhao ZS, O'Brien PJ: The prevention of CCl4-induced liver necrosis in mice by naturally occurring methylenedioxybenzenes. Toxicol Appl Pharmacol. 1996 Oct;140(2):411-21. Pretreatment with isosafrole, dihydrosafrole, and benzodioxole at dosages as low as 10 mg/kg significantly prevented the increase in plasma transaminase levels and histochemical changes associated with CCl4-induced liver necrosis, whereas piperonyl butoxide (PBO), sesamol, and did not prevent CCl4 hepatotoxicity even at 200 mg/kg. The protective effects of isosafrole, and benzodioxole were therefore predominantly attributed to their ability to inactivate CYP2E1, the major isozyme involved in CCl4 bioactivation. |
1(0,0,0,1) | Details |