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piperonyl butoxide

Identification (Source:EPA,EU)

ID	1802
Name	piperonyl butoxide
CAS	51-03-6
IUPAC
Inchi	InChI=1S/C19H30O5/c1-3-5-7-20-8-9-21-10-11-22-14-17-13-19-18(23-15-24-19)12-16(17)6-4-2/h12-13H,3-11,14-15H2,1-2H3
CIPAC	33
EPA Code	067501
Formula	C19H30O5
SMILES	O1c2cc(c(cc2OC1)COCCOCCOCCCC)CCC
Status	NOT PPP

Classification

Mode of Action	Blocks pests natural detoxification system. Synergist. P450-dependent monooxygenase inhibitor.
Pesticide Type	Other product constituent, Veterinary treatment
Chemical Group	Cyclic aromatic
Classification	Synergists

Properties (Source:PubChem)

Molecular Weight	338.44
Physical State	Colourless to yellow oily liquid
AlogP	3.867
H-Bond Donor	0
H-Bond Acceptor	5
Surface Area	352.88
Polar Surface Area	46.15

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	0.24 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.51 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.12 mg l-1
Birds	Acute		LD50	> 2250 mg kg-1
Fish	Acute	96 hour	LC50	5.3 mg l-1
Honeybees	Acute	48 hour	LD50	294 μg bee-1
Mammals	Acute oral		LD50	> 7220 mg kg-1
Mammals	Short term dietary		NOEL	30 mg kg-1
	Bio-concentration factor		CT50	Not available days
	Bio-concentration factor		BCF	260

Related targets

Target Name	RScore (About this table)
cytochrome P450 (protein family or complex)	4378(28,84,99,383)	Details
Acetylcholinesterase	629(5,10,10,79)	Details
cytochrome P450 monooxygenases	558(5,9,9,38)	Details
c jun	225(2,4,4,5)	Details
demethylase	207(1,4,7,22)	Details
CYP1A2	158(1,3,4,13)	Details
Microsomal monooxygenase	145(1,3,3,5)	Details
glutathione S transferase	167(1,2,6,37)	Details
cytochrome c	115(1,2,2,5)	Details
monoamine oxidase	115(1,2,2,5)	Details
hemoglobin (protein family or complex)	87(1,1,1,7)	Details
beta glucuronidase	84(1,1,1,4)	Details
sulfotransferase	81(1,1,1,1)	Details
peroxisome proliferator activated receptor alpha	81(1,1,1,1)	Details
AP 1 (protein family or complex)	81(1,1,1,1)	Details
HGPRT	81(1,1,1,1)	Details
microsomal monooxygenases	67(0,2,2,7)	Details
Lipoxygenase (protein family or complex)	65(0,2,2,5)	Details
ATPase	46(0,1,2,11)	Details
lactate dehydrogenase (protein family or complex)	45(0,1,2,10)	Details
PK1	41(0,1,2,6)	Details
PCNA	40(0,1,2,5)	Details
catalase	39(0,1,2,4)	Details
CYP1B1	39(0,1,1,9)	Details
Ah receptor	37(0,1,1,7)	Details
GABA receptor (protein family or complex)	37(0,1,1,7)	Details
alanine aminotransferase	35(0,1,1,5)	Details
cytochrome P450 reductase	34(0,1,1,4)	Details
Salvador	34(0,1,1,4)	Details
alcohol dehydrogenase (protein family or complex)	32(0,1,1,2)	Details
malate dehydrogenase	31(0,1,1,1)	Details
aryl hydrocarbon hydroxylase	31(0,1,1,1)	Details
CS2	31(0,1,1,1)	Details
PTPE	31(0,1,1,1)	Details
CYP1A1	18(0,0,1,13)	Details
C18	14(0,0,1,9)	Details
P glycoprotein	13(0,0,0,13)	Details
superoxide dismutase	13(0,0,2,3)	Details
sodium channel (protein family or complex)	12(0,0,0,12)	Details
CK 8	10(0,0,1,5)	Details
glutamyl transpeptidase	10(0,0,1,5)	Details
cholinesterase	10(0,0,0,10)	Details
CYP3A4	10(0,0,1,5)	Details
RAPTOR	9(0,0,1,4)	Details
uroporphyrinogen decarboxylase	8(0,0,0,8)	Details
F11	8(0,0,1,3)	Details
glucosylceramide synthase	8(0,0,1,3)	Details
TESS	7(0,0,1,2)	Details
epoxide hydrolase	7(0,0,0,7)	Details
transferrin receptor	7(0,0,1,2)	Details
cytokeratin	7(0,0,1,2)	Details
ceruloplasmin	7(0,0,1,2)	Details
phospholipase A2	6(0,0,0,6)	Details
CYP2B	6(0,0,0,6)	Details
tryptophan hydroxylase	6(0,0,0,6)	Details
metallothionein (protein family or complex)	6(0,0,1,1)	Details
connexin 32	6(0,0,1,1)	Details
MT 1	6(0,0,1,1)	Details
chloride channel (protein family or complex)	5(0,0,0,5)	Details
glutathione transferase	5(0,0,0,5)	Details
interleukin 4	5(0,0,0,5)	Details
calpain (protein family or complex)	4(0,0,0,4)	Details
acetylcholine receptor (protein family or complex)	4(0,0,0,4)	Details
TGFbeta	4(0,0,0,4)	Details
aspartate aminotransferase	4(0,0,0,4)	Details
albumin	3(0,0,0,3)	Details
c Myc	3(0,0,0,3)	Details
cytochrome b5	3(0,0,0,3)	Details
NADH dehydrogenase	3(0,0,0,3)	Details
IgE	3(0,0,0,3)	Details
ferrochelatase	3(0,0,0,3)	Details
PTEN	3(0,0,0,3)	Details
enolase	3(0,0,0,3)	Details
glycolytic enzymes	3(0,0,0,3)	Details
activating transcription factor 3	2(0,0,0,2)	Details
coagulation factor VIII	2(0,0,0,2)	Details
signal transducer and activator of transcription 6	2(0,0,0,2)	Details
von Willebrand factor	2(0,0,0,2)	Details
G6PD	2(0,0,0,2)	Details
Sulfite Oxidase	2(0,0,0,2)	Details
NADH:ubiquinone oxidoreductase (protein family or complex)	2(0,0,0,2)	Details
protein is	2(0,0,0,2)	Details
NPYR	2(0,0,0,2)	Details
interferon gamma	2(0,0,0,2)	Details
mitogen activated protein kinase (protein family or complex)	2(0,0,0,2)	Details
epidermal growth factor receptor	2(0,0,0,2)	Details
glucose 6 phosphatase	2(0,0,0,2)	Details
CYP2E1	2(0,0,0,2)	Details
protein kinase C (protein family or complex)	2(0,0,0,2)	Details
brains	2(0,0,0,2)	Details
SRBC	2(0,0,0,2)	Details
enolases (protein family or complex)	2(0,0,0,2)	Details
transferase	2(0,0,0,2)	Details

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