Protein Information

Name superoxide dismutase
Synonyms IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD…

Compound Information

Name piperonyl butoxide
CAS 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
8180564 Stewart RJ, Mason SW, Taira MT, Hasson GE, Naito MS, Yamaguchi KT: Effect of radical scavengers and hyperbaric oxygen on smoke-induced pulmonary edema. Undersea Hyperb Med. 1994 Mar;21(1):21-30.

The following free radical scavengers were given as bolus infusions at the beginning of fluids resuscitation: superoxide dismutase, catalase, butylated hydroxytoluene/piperonyl butoxide, and mannitol.
6(0,0,1,1) Details
14522598 Blankenship AL, Hilscherova K, Nie M, Coady KK, Villalobos SA, Kannan K, Powell DC, Bursian SJ, Giesy JP: Mechanisms of TCDD-induced abnormalities and embryo lethality in white leghorn chickens. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Sep;136(1):47-62.

Treatments included TCDD (150 ng/kg), triolein (vehicle control), and various co-treatments including MnTBAP (a mimetic of superoxide dismutase), piperonyl butoxide, piroxicam, vitamin A acetate, and vitamin E succinate.
6(0,0,1,1) Details
1965745 Ishiyama H, Ogino K, Shimomura Y, Kanbe T, Hobara T: Hepatotoxicity of diethyldithiocarbamate in rats. Pharmacol Toxicol. 1990 Nov;67(5):426-30.

A sustained inhibition in the liver of Cu,Zn-superoxide dismutase (Cu-SOD) activity was observed following DDC treatment.
Desferrioxamine (a chelator of iron) and piperonyl butoxide (an inhibitor of cytochrome P-450) prevented DDC-induced increases of both ALT and TBARS, but GSH did not, DDC hepatotoxicity was not changed by phenobarbital induction.
1(0,0,0,1) Details
4062959 Sinha BK, Strong J, Gibson NW, Kalyanaraman B: Mechanism of DNA strand breaks by mitonafide, an imide derivative of 3-nitro-1,8-naphthalic acid. Biochem Pharmacol. 1985 Nov 1;34(21):3845-52.


The formation of the amine metabolite was not inhibited by SKF-525A, metyrapone or piperonyl butoxide, indicating that the cytochrome P-450 was not involved in this reduction.
0(0,0,0,0) Details
7191853 Kedderis GL, Koop DR, Hollenberg PF: N-Demethylation reactions catalyzed by chloroperoxidase. J Biol Chem. 1980 Nov 10;255(21):10174-82.


The chloroperoxidase-catalyzed demethylations were inhibited by inhibitors of cytochrome P-450 such as azide or n-propyl gallate, but not by metyrapone, SKF-525A, or piperonyl butoxide.
0(0,0,0,0) Details