| Name | CYP2B |
|---|---|
| Synonyms | CYP2B; CYP2B7; CYP2B7P; CYP2B protein; CYP2B7P1; CYP2B7P1 protein; CYP2B7P1 proteins |
| Name | piperonyl butoxide |
|---|---|
| CAS | 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9817083 | Lee PC, Marquardt M, Lech JJ: Metabolism of nonylphenol by rat and human microsomes. . Toxicol Lett. 1998 Oct 15;99(2):117-26. Product formation was dependent and inhibited by the cytochrome P450 inhibitors, piperonyl butoxide and SKF525. The metabolism of NPs using microsomes from phenobarbital-treated rats was inhibited by 4-amino-2, 6-dinitro-1-t-butylxylene, a specific CYP2B enzyme inhibitor. |
3(0,0,0,3) | Details |
| 19851987 | Park D, Kim S, Kang H, Oh J, Jang JY, Shin S, Kim TK, Choi YJ, Lee SH, Kim KY, Joo SS, Kim YB: Preventive effect of piperonyl butoxide on cyclophosphamide-induced teratogenesis in rats. Birth Defects Res B Dev Reprod Toxicol. 2009 Oct;86(5):402-8. The pre-treatment of PBO greatly decreased mRNA expression and activity of hepatic CYP2B, which metabolizes cyclophosphamide into teratogenic acrolein and cytotoxic phosphoramide mustard. |
2(0,0,0,2) | Details |
| 9928682 | Ratra GS, Cottrell S, Powell CJ: Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene. Toxicol Sci. 1998 Nov;46(1):185-96. Pretreatment of male Han Wistar rats with beta-naphthoflavone, phenobarbitone, butylated hydroxytoluene, piperonyl butoxide, Aroclor 1254, or agents known to modify hepatic CYP, all afforded some degree of protection against a hepatotoxic dose of methapyrilene (150 mg/kg x 3 days p.o.), as assessed by clinical chemistry and histology. Protection against hepatic damage was strongly associated with beta-naphthoflavone induction of CYP1A and phenobarbitone-associated CYP2B induction. |
1(0,0,0,1) | Details |