| Name | glutathione S transferase |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | piperonyl butoxide |
|---|---|
| CAS | 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3711591 | Siddiqui MK, Anjum F, Mahboob M, Quadri SS: Effects of DDT and piperonyl butoxide on the metabolic alterations in pigeon (Columbia livia). J Environ Sci Health B. 1986 Apr;21(2):115-24. P450) and cytosolic glutathione-S-transferase (GST) activity in pigeon were studied after 24 hours of treatment. |
1(0,0,0,1) | Details |
| 19937914 | Feng Y, Wu Q, Wang S, Chang X, Xie W, Xu B, Zhang Y: Cross-resistance study and biochemical mechanisms of thiamethoxam resistance in B-biotype Bemisia tabaci (Hemiptera: Aleyrodidae). Pest Manag Sci. 2010 Mar;66(3):313-8. Piperonyl butoxide (PBO) and triphenyl (TPP) exhibited significant synergism on thiamethoxam effects in the TH-R strain (3.14- and 2.37-fold respectively). |
0(0,0,0,0) | Details |
| 12680931 | Montagna CM, Anguiano OL, Gauna LE, Pechen de d-Angelo AM: Mechanisms of resistance to DDT and pyrethroids in Patagonian populations of Simulium blackflies. Med Vet Entomol. 2003 Mar;17(1):95-101. Pre-treatment with the synergist piperonyl butoxide (PBO) reduced both DDT and fenvalerate resistance, indicating that resistance was partly due to monooxygenase inhibition. |
0(0,0,0,0) | Details |
| 16032654 | Xu Q, Liu H, Zhang L, Liu N: Resistance in the mosquito, Culex quinquefasciatus, and possible mechanisms for resistance. Pest Manag Sci. 2005 Nov;61(11):1096-102. Resistance to permethrin in MAmCq (G1) and HAmCq (G3) was partially suppressed by piperonyl butoxide (PBO), S,S,S-tributylphosphorotrithioate (DEF) and diethyl (DEM), inhibitors of cytochrome P450 monooxygenases, hydrolases and glutathione S-transferases (GST), respectively, suggesting these three enzyme families are important in conferring permethrin resistance in both strains. |
81(1,1,1,1) | Details |
| 17514638 | Willoughby L, Batterham P, Daborn PJ: Piperonyl butoxide induces the expression of cytochrome P450 and glutathione S-transferase genes in Drosophila melanogaster. Pest Manag Sci. 2007 Aug;63(8):803-8. |
7(0,0,1,2) | Details |
| 18506673 | Wang Y, Gao C, Xu Z, Zhu YC, Zhang J, Li W, Dai D, Lin Y, Zhou W, Shen J: Buprofezin susceptibility survey, resistance selection and preliminary determination of the resistance mechanism in Nilaparvata lugens (Homoptera: Delphacidae). Pest Manag Sci. 2008 Oct;64(10):1050-6. Synergism tests showed that O,O-diethyl-O-phenyl phosphorothioate (SV1), piperonyl butoxide (PBO) and diethyl (DEM) increased buprofezin toxicity in the resistant strain by only 1.5-1.6 fold, suggesting that esterases, P450-monooxygenases and glutathione S-transferases had no substantial effect on buprofezin resistance development. |
0(0,0,0,0) | Details |
| 18590597 | Van Pottelberge S, Van Leeuwen T, Nauen R, Tirry L: Resistance mechanisms to mitochondrial electron transport inhibitors in a field-collected strain of Tetranychus urticae Koch (Acari: Tetranychidae). Bull Entomol Res. 2009 Feb;99(1):23-31. Epub 2008 Jul 1. Tebufenpyrad resistance could only be synergized after pre-treatment with the monooxygenase inhibitor piperonyl butoxide (PBO), whereas pyridaben resistance was strongly synergized both by PBO and the esterase inhibitor S,S,S-tributylphosphorotrithioate (DEF). |
0(0,0,0,0) | Details |
| 17764719 | Damasio J, Guilhermino L, Soares AM, Riva MC, Barata C: Biochemical mechanisms of resistance in Daphnia magna exposed to the insecticide fenitrothion. Chemosphere. 2007 Nov;70(1):74-82. Epub 2007 Aug 30. Inhibition of mixed- function oxidases (MFOs) by piperonyl butoxide (PBO) increased the tolerance to fenitrothion by almost 20-fold in all clones without altering their relative ranking of resistance. |
0(0,0,0,0) | Details |
| 19548293 | Achaleke J, Martin T, Ghogomu RT, Vaissayre M, Brevault T: Esterase-mediated resistance to pyrethroids in field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) from Central Africa. Pest Manag Sci. 2009 Oct;65(10):1147-54. Pretreatment with piperonyl butoxide (PBO) resulted in significant synergism with cypermethrin in 6/10 field populations, but not in the laboratory-selected strain, indicating that additional mechanisms such as mixed-function oxidase (MFO) may be involved in field resistance. |
0(0,0,0,0) | Details |
| 19309364 | Taniai E, Kawai M, Dewa Y, Nishimura J, Harada T, Saegusa Y, Matsumoto S, Takahashi M, Mitsumori K, Shibutani M: Crosstalk between PTEN/Akt2 and TGFbeta signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model. Cancer Sci. 2009 May;100(5):813-20. Epub 2009 Mar 20. The cellular localization of related molecules was examined in liver cell foci expressing glutathione S-transferase placental form (GST-P) at the early stage of tumor promotion by fenbendazole (FB), piperonyl butoxide, or thioacetamide. |
6(0,0,1,1) | Details |
| 12088537 | Fragoso DB, Guedes RN, Guedes RN, Picanco MC, Zambolim L: Insecticide use and organophosphate resistance in the coffee leaf miner Leucoptera coffeella (Lepidoptera: Lyonetiidae). Bull Entomol Res. 2002 Jun;92(3):203-12. Results from insecticide bioassays with synergists (diethyl piperonyl butoxide and triphenyl suggested that cytochrome P450-dependent monooxygenases may play a major role in resistance with minor involvement of esterases and glutathione S-transferases. |
6(0,0,1,1) | Details |
| 20091025 | Mizukami S, Ichimura R, Kemmochi S, Taniai E, Shimamoto K, Ohishi T, Takahashi M, Mitsumori K, Shibutani M: Induction of GST-P-positive proliferative lesions facilitating lipid peroxidation with possible involvement of transferrin receptor up-regulation and ceruloplasmin down-regulation from the early stage of liver tumor promotion in rats. Arch Toxicol. 2010 Apr;84(4):319-31. Epub 2009 Dec 20. To elucidate the role of metal-related molecules in hepatocarcinogenesis, we examined immunolocalization of transferrin receptor (Tfrc), ceruloplasmin (Cp) and metallothionein (MT)-1/2 in relation to liver cell foci positive for glutathione-S-transferase placental form (GST-P) in the early stage of tumor promotion by fenbendazole (FB), phenobarbital, piperonyl butoxide or thioacetamide in a rat two-stage hepatocarcinogenesis model. |
6(0,0,1,1) | Details |
| 19367570 | Mosallanejad H, Smagghe G: Biochemical mechanisms of methoxyfenozide resistance in the cotton leafworm Spodoptera littoralis. Pest Manag Sci. 2009 Jul;65(7):732-6. When the inhibitors piperonyl butoxide (PBO), S,S,S-tributyl phosphorotrithioate (DEF) and diethyl were tested as synergists, the respective synergistic ratios were 0.97, 0.96 and 1.0 for the susceptible strain, and 2.2, 0.96 and 1.1 for the resistant strain. |
0(0,0,0,0) | Details |
| 19533589 | Wang D, Qiu X, Ren X, Zhang W, Wang K: Effects of spinosad on Helicoverpa armigera (Lepidoptera: Noctuidae) from China: tolerance status, synergism and enzymatic responses. Pest Manag Sci. 2009 Sep;65(9):1040-6. The toxicity of spinosad could be synergised by piperonyl butoxide (PBO) and triphenylphosphate (TPP), but not by diethyl maleate (DEM). |
0(0,0,0,0) | Details |
| 20298109 | Mohammadi Sharif M, Hejazi MJ, Mohammadi A, Rashidi MR: Resistance status of the Colorado potato beetle, Leptinotarsa decemlineata, to endosulfan in East Azarbaijan and Ardabil provinces of Iran. J Insect Sci. 2007;7:1-7. Two insecticide synergists, piperonyl butoxide and S,S,S-tributylphosphorotrithioate, reduced resistance 2.3 and 3.5 times, respectively. |
0(0,0,0,0) | Details |
| 11886776 | Tsagkarakou A, Pasteur N, Cuany A, Chevillon C, Navajas M: Mechanisms of resistance to organophosphates in Tetranychus urticae (Acari: Tetranychidae) from Greece. Insect Biochem Mol Biol. 2002 Apr;32(4):417-24. It is shown that S,S,S-tributyl phosphorotrithioate, a synergist that inhibits esterases and glutathione S-transferases, and piperonyl butoxide, a synergist that inhibits cytochrome P450 mediated monooxygenases, did not affect the level of methyl-parathion or methomyl resistance in RLAB and that resistance ratios to both insecticides did not change significantly in the presence of either synergist. |
0(0,0,0,0) | Details |
| 9566212 | Sivori JL, Casabe N, Zerba EN, Wood EJ: Induction of glutathione S-transferase activity in Triatoma infestans. Mem Inst Oswaldo Cruz. 1997 Nov-Dec;92(6):797-802. Meanwhile, general insecticide synergist such as piperonyl butoxide (160 micrograms/insect) increased the GST-activity in the range of 120-140%. |
2(0,0,0,2) | Details |
| 7507502 | Hemingway J, Small GJ, Monro AG: Possible mechanisms of organophosphorus and insecticide resistance in German cockroaches (Dictyoptera: Blattelidae) from different geographical areas. J Econ Entomol. 1993 Dec;86(6):1623-30. Increased levels of glutathione S-transferase activity were found in four strains. Synergist studies with piperonyl butoxide indicated that multifunction mono-oxidases are probably involved in resistance to chlorpyrifos in six strains and in resistance to propoxur in seven strains. |
2(0,0,0,2) | Details |
| 12823830 | Enayati AA, Vatandoost H, Ladonni H, Townson H, Hemingway J: Molecular evidence for a kdr-like pyrethroid resistance mechanism in the malaria vector mosquito Anopheles stephensi. Med Vet Entomol. 2003 Jun;17(2):138-44. Activities of some enzymes likely to confer pyrethroid-resistance (i.e. esterases, monooxygenases and glutathione S-transferases) were significantly higher in the permethrin-resistant than in the susceptible strain, but the use of synergists--piperonyl butoxide (PBO) to inhibit monooxygenases and/or tribufos (DEF) to inhibit esterases--did not fully prevent resistance in larvae (permethrin LC50 reduced by only 51-68%), indicating the involvement of another mechanism. |
0(0,0,0,0) | Details |
| 10887565 | Rodriguez MM, Bisset JA, Mila LH, Calvo E, Diaz C, Alain Soca L: [Levels of insecticide resistance and its mechanisms in a strain of Aedes aegypti of Santiago de Cuba]. Rev Cubana Med Trop. 1999 May-Aug;51(2):83-8. Piperonyl butoxide synergist disclosed that multifunction oxidases were not involved in the resistance to any of the evaluated insecticides. Biochemical techniques were applied to detect esterase-, glutathione-S-transferase- and acetylcholineaterase-mediated resistance mechanisms of Aedes aegypti. |
2(0,0,0,2) | Details |
| 8079362 | Foster JR, Green T, Smith LL, Tittensor S, Wyatt I: Methylene an inhalation study to investigate toxicity in the mouse lung using morphological, biochemical and Clara cell culture techniques. Toxicology. 1994 Aug 12;91(3):221-34. Both cytochrome P-450 (CYP)- and glutathione S-transferase (GST)-dependent metabolism of MC are known to occur. Vacuolated bronchiolar cells were seen in mice exposed to 2000 and 4000 ppm MC but were not seen at lower concentrations, while addition of the CYP inhibitor, piperonyl butoxide, significantly reduced the bronchiolar cell vacuolation seen following exposure to 2000 ppm MC. |
1(0,0,0,1) | Details |
| 19125173 | Pasay C, Arlian L, Morgan M, Gunning R, Rossiter L, Holt D, Walton S, Beckham S, McCarthy J: The effect of insecticide synergists on the response of scabies mites to pyrethroid acaricides. PLoS Negl Trop Dis. 2009;3(1):e354. Epub 2009 Jan 6. METHODOLOGY/PRINCIPAL FINDINGS: To determine the role of metabolic degradation as a mechanism for acaricide resistance in scabies mites, PBO (piperonyl butoxide), DEF (S,S,S-tributyl phosphorotrithioate) and DEM (diethyl were first tested for synergistic activity with permethrin in a bioassay of mite killing. Then, to investigate the relative role of specific metabolic pathways inhibited by these synergists, enzyme assays were developed to measure esterase, glutathione S-transferase (GST) and cytochrome P450 monooxygenase (cytochrome P450) activity in mite extracts. |
1(0,0,0,1) | Details |
| 10826201 | Jensen SE: Mechanisms associated with methiocarb resistance in Frankliniella occidentalis (Thysanoptera: Thripidae). J Econ Entomol. 2000 Apr;93(2):464-71. Including the synergists piperonyl butoxide, a cytochrome P-450 monooxygenase inhibitor, or S,S,S-tributylphosphorotrithioate, an esterase inhibitor, in the methiocarb bioassays partially suppressed resistance in the most resistant populations. In vitro assays of general esterase, glutathione S-transferase, and acetylcholinesterase activities showed increased activity in some of the resistant populations and increased activity of the enzymes after methiocarb selection on one of the populations. |
1(0,0,0,1) | Details |
| 10194754 | Hemingway J, Miller J, Mumcuoglu KY: Pyrethroid resistance mechanisms in the head louse Pediculus capitis from Israel: implications for control. Med Vet Entomol. 1999 Feb;13(1):89-96. We identified a glutathione S-transferase (GST)-based mechanism of DDT resistance in the Israeli head lice. However, the lack of synergism of phenothrin resistance by piperonyl butoxide suggests that a non-oxidative mechanism is also present in the resistant lice. |
1(0,0,0,1) | Details |
| 15154513 | Ahmad M, Hollingworth RM: Synergism of insecticides provides evidence of metabolic mechanisms of resistance in the obliquebanded leafroller Choristoneura rosaceana (Lepidoptera: Tortricidae). Pest Manag Sci. 2004 May;60(5):465-73. These studies indicate that enhanced detoxification, often mediated by cytochrome P-450 monooxygenases, but with probable esterase and glutathione S-transferase contributions in some cases, is the major mechanism imparting resistance to different insecticides in C. rosaceana. The interactions between six insecticides (indoxacarb, cypermethrin, chlorpyrifos, azinphosmethyl, tebufenozide and chlorfenapyr) and three potential synergists, (piperonyl butoxide (PBO), S,S,S-tributyl phosphorotrithioate (DEF) and diethyl (DEM)) were studied by dietary exposure in a multi-resistant and a susceptible strain of the obliquebanded leafroller, Choristoneura rosaceana (Harris). |
1(0,0,0,1) | Details |
| 18648771 | Muguruma M, Kawai M, Dewa Y, Nishimura J, Saegusa Y, Yasuno H, Jin M, Matsumoto S, Takabatake M, Arai K, Mitsumori K: Threshold dose of piperonyl butoxide that induces reactive species-mediated hepatocarcinogenesis in rats. Arch Toxicol. 2009 Feb;83(2):183-93. Epub 2008 Jul 22. Histopathologically, Glutathione S-transferase placental form (GST-P)-positive foci were significantly increased in a dose-dependent manner in rats given 0.25% PBO or higher. |
1(0,0,0,1) | Details |
| 17421051 | Wu G, Miyata T, Kang CY, Xie LH: Insecticide toxicity and synergism by enzyme inhibitors in 18 species of pest insect and natural enemies in crucifer vegetable crops. Pest Manag Sci. 2007 May;63(5):500-10. Meanwhile, the inhibitory effects of these enzyme inhibitors on the activities of acetylcholinesterases (AChE), carboxyesterases (CarE) and glutathione-S-transferases (GST), in vivo, were also studied. Piperonyl butoxide (PB) exhibited low toxicities to the herbivorous pest insects and ladybirds, but high toxicities to the eight parasitoids. |
1(0,0,0,1) | Details |
| 19542331 | Subramanian V, Yadav JS: Role of P450 monooxygenases in the degradation of the endocrine-disrupting chemical nonylphenol by the white rot fungus Phanerochaete chrysosporium. Appl Environ Microbiol. 2009 Sep;75(17):5570-80. Epub 2009 Jun 19. The P450 enzyme inhibitor piperonyl butoxide caused significant inhibition (approximately 75%) of the degradation activity in nutrient-rich malt extract (ME) cultures but no inhibition in defined low- (LN) cultures, indicating an essential role of P450 monooxygenase (s) in NP degradation under nutrient-rich conditions. The P450 oxidoreductase (POR), glutathione S-transferase (gst), and cellulose metabolism genes were also induced in ME cultures. |
1(0,0,0,1) | Details |
| 8294621 | Hemingway J, Dunbar SJ, Monro AG, Small GJ: Pyrethroid resistance in German cockroaches (Dictyoptera: Blattelidae): resistance levels and underlying mechanisms. J Econ Entomol. 1993 Dec;86(6):1631-8. Possible resistance mechanisms detected in these populations included elevated levels of cytochrome P450, general esterase and glutathione S-transferase, and nerve insensitivity (kdr-type resistance). Resistance was synergized by piperonyl butoxide in some strains. |
1(0,0,0,1) | Details |
| 3966241 | Storer RD, Conolly RB: An investigation of the role of microsomal oxidative metabolism in the in vivo genotoxicity of 1,2-dichloroethane. Toxicol Appl Pharmacol. 1985 Jan;77(1):36-46. In vitro studies have demonstrated that two different metabolic pathways, conjugation mediated by the glutathione S-transferases and microsomal oxidation, may be involved in the genotoxicity and carcinogenicity of 1,2-dichloroethane (DCE). To evaluate the importance of microsomal oxidative metabolism in the bioactivation of DCE in vivo, male B6C3F1 mice were pretreated with piperonyl butoxide (PIB), an inhibitor of microsomal oxidative metabolism, and the effect of this pretreatment on the extent of hepatic DNA damage produced by DCE was determined 4 hr after DCE administration. |
1(0,0,0,1) | Details |
| 8183245 | Chichester CH, Buckpitt AR, Chang A, Plopper CG: Metabolism and cytotoxicity of naphthalene and its metabolites in isolated murine Clara cells. Mol Pharmacol. 1994 Apr;45(4):664-72. Naphthalene-induced decreases in cell viability were blocked by preincubation of Clara cells with the cytochrome P450 monooxygenase inhibitor piperonyl butoxide. To establish the capability of these cells to metabolize an agent that causes Clara cell-selective toxicity in vivo, we evaluated the metabolism of naphthalene in isolated cells under two distinct conditions, i.e., in homogenized cell preparations supplemented with and glutathione S-transferases and in intact cells. |
1(0,0,0,1) | Details |
| 16162970 | Brandon EF, Meijerman I, Klijn JS, den Arend D, Sparidans RW, Lazaro LL, Beijnen JH, Schellens JH: In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction. Anticancer Drugs. 2005 Oct;16(9):935-43. In-vitro studies have shown that ET-743 is mainly metabolized by cytochrome P450 (CYP) 3A4, but also by 2C9, 2C19, 2D6 and 2E1, and the phase II enzymes diphosphoglucuronosyl transferase and glutathione-S-transferase. Potent cytotoxic activity of ET-743 after 120 h treatment was observed, which could be increased in combination with the CYP inhibitors (3A4), phenanthrene (substrate for 2E1, 3A4), piperonyl butoxide (3A), proadifen (2C9, 2E1, 3A4), ritonavir (3A4), and (2C9, 2C19). |
1(0,0,0,1) | Details |
| 14680115 | Li AY, Davey RB, Miller RJ, George JE: Resistance to coumaphos and diazinon in Boophilus microplus (Acari: Ixodidae) and evidence for the involvement of an oxidative detoxification mechanism. J Med Entomol. 2003 Jul;40(4):482-90. Bioassays with diethyl (DEM) revealed a significant correlation between DEM synergism ratios and LC50 estimates for diazinon, suggesting a possible role for glutathione S-transferases in diazinon detoxification. Piperonyl butoxide (PBO) reduced coumaphos toxicity in susceptible strains, but synergized coumaphos toxicity in resistant strains. |
1(0,0,0,1) | Details |
| 18544911 | Yasuno H, Nishimura J, Dewa Y, Muguruma M, Takabatake M, Murata Y, Shibutani M, Mitsumori K: Modifying effect of Siraitia grosvenori extract on piperonyl butoxide-promoted hepatocarcinogenesis in rats. J Toxicol Sci. 2008 May;33(2):197-207. Liver immunohistochemistry revealed that although the PBO-mediated increase in the number of glutathione S-transferase placental form (GST-P)-positive foci and proliferating cell nuclear antigen-positive cells remained unaltered with SGE coadministration, the area of the GST-P-positive foci was increased. |
1(0,0,0,1) | Details |
| 18615705 | Yang ML, Zhang JZ, Zhu KY, Xuan T, Liu XJ, Guo YP, Ma EB: Mechanisms of organophosphate resistance in a field population of oriental migratory locust, Locusta migratoria manilensis (Meyen). Arch Insect Biochem Physiol. 2009 May;71(1):3-15. The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists [triphenyl (TPP), piperonyl butoxide (PBO), and diethyl (DEM)], activities of major detoxification enzymes [general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)], and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen). |
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| 15262281 | Yang Y, Wu Y, Chen S, Devine GJ, Denholm I, Jewess P, Moores GD: The involvement of microsomal oxidases in pyrethroid resistance in Helicoverpa armigera from Asia. Insect Biochem Mol Biol. 2004 Aug;34(8):763-73. In the resistant strains, minor increases in glutathione S-transferase activity (to the substrates CDNB and DCNB), and esterase activity (to the substrate alpha-naphthyl further suggested that, of the putative metabolic mechanisms, oxidases are the most important. Selection with a mixture of fenvalerate and piperonyl butoxide (PBO) for 14 generations ('YGFP') resulted in resistance ratios of 2510, 2920 and 286. |
1(0,0,0,1) | Details |
| 16937654 | Johnson RM, Wen Z, Schuler MA, Berenbaum MR: Mediation of pyrethroid insecticide toxicity to honey bees (Hymenoptera: Apidae) by cytochrome P450 monooxygenases. J Econ Entomol. 2006 Aug;99(4):1046-50. Metabolic insecticide resistance in other insects is mediated by three major groups of detoxifying enzymes: the cytochrome P450 monooxygenases (P450s), the carboxylesterases (COEs), and the glutathione S-transferases (GSTs). To test the role of metabolic detoxification in mediating the relatively low toxicity of tau-fluvalinate compared with more toxic pyrethroid insecticides, we examined the effects of piperonyl butoxide (PBO), S,S,S-tributylphosphorotrithioate (DEF), and diethyl (DEM) on the toxicity of these pyrethroids. |
1(0,0,0,1) | Details |
| 16363165 | Liu H, Xu Q, Zhang L, Liu N: Chlorpyrifos resistance in mosquito Culex quinquefasciatus. J Med Entomol. 2005 Sep;42(5):815-20. A synergism study showed that resistance to chlorpyrifos in MAmCq and HAmCq was not suppressed by piperonyl butoxide (PBO) and S,S,S,-tributylphosphorotrithioate (DEF), suggesting that P450 monooxygenase- and hydrolase-mediated detoxication does not contribute to chlorpyrifos resistance in either strain. However, DEM enhanced toxicity of chlorpyrifos to MAmCq 2.5-fold, indicating that glutathione S-transferase (GST)-mediated detoxication may play a minor role in the resistance of MAmCq. |
1(0,0,0,1) | Details |
| 11603736 | Yang X, Zhu KY, Buschman LL, Margolies DC: Comparative susceptibility and possible detoxification mechanisms for selected miticides in banks grass mite and two-spotted spider mite (Acari: Tetranychidae). Exp Appl Acarol. 2001;25(4):293-9. On the other hand, the synergist piperonyl butoxide (PBO) increased the toxicities of bifenthrin and lambda-cyhalothrin by 6.0- and 2.6-fold, respectively, against BGM, and by 4.5- and 1.9-fold, respectively, against TSM. The significant synergism with these pyrethroids of all three tested synergists (except for DEM with lambda-cyhalothrin against TSM) suggests that esterases, glutathione S-transferases, and cytochrome P450 monooxygenases all play important roles in their detoxification. |
1(0,0,0,1) | Details |
| 2050025 | Plopper CG, Chang AM, Pang A, Buckpitt AR: Use of microdissected airways to define metabolism and cytotoxicity in murine bronchiolar epithelium. Exp Lung Res. 1991 Mar-Apr;17(2):197-212. Glutathione S-transferase activity was measured in all compartments, with the highest activities in trachea and lowest in distal bronchiole and pulmonary vein. Pre-incubation of the explants with piperonyl butoxide, a cytochrome P-450 monooxygenase inhibitor, prevented naphthalene-induced cytotoxicity. |
1(0,0,0,1) | Details |
| 17498859 | Muguruma M, Unami A, Kanki M, Kuroiwa Y, Nishimura J, Dewa Y, Umemura T, Oishi Y, Mitsumori K: Possible involvement of oxidative stress in piperonyl butoxide induced hepatocarcinogenesis in rats. Toxicology. 2007 Jul 1;236(1-2):61-75. Epub 2007 Apr 6. Hepatocytes exhibited centrilobular hypertrophy and increased glutathione S-transferase placental form (GST-P) positive foci formation. |
1(0,0,0,1) | Details |
| 10918309 | David JP, Rey D, Cuany A, Amichot M, Meyran JC: Comparative ability to detoxify alder leaf litter in field larval mosquito collections. Arch Insect Biochem Physiol. 2000 Aug;44(4):143-50. The larvicidal effects of polyphenols from dietary alder leaf litter were investigated in different field collections of three detritivorous Aedes taxa (Ae. detritus, Ae. cataphylla, Ae. rusticus) and compared to the cytochrome P450 monooxygenase, glutathione S-transferase, and esterase activities. Furthermore, the role of P450 enzymes in the mechanism of resistance to alder polyphenols was suggested by the synergistic effect in vivo of piperonyl butoxide in the resistant Ae. rusticus. |
1(0,0,0,1) | Details |
| 6547180 | Fouin-Fortunet H, Letteron P, Tinel M, Degott C, Flejou JF, Pessayre D: Mechanism for isaxonine hepatitis. J Pharmacol Exp Ther. 1984 Jun;229(3):851-8. Coincubation of 0.4 mM [3H] with 4 mM isaxonine , an -generating system, glutathione S-transferase and mouse liver microsomes, followed by thin-layer chromatography of the incubation mixture, resulted in the appearance of a 3H-labeled peak with characteristics consistent with a - isaxonine metabolite adduct: this peak was absent if either isaxonine or the -generating system was omitted and was decreased if the transferase was omitted. In vivo, the concentrations of hepatic and were markedly decreased 2.5 hr after administration of isaxonine (4 mmol X kg-1 i.p.); this depletion of was prevented essentially by pretreatment with piperonyl butoxide. |
1(0,0,0,1) | Details |
| 3358959 | Nedel'kina SV, Solomennikova IV, Lukashina NS, Leonova IN, Raushenbakh IIu: [Enzymatic systems of insecticide detoxication in a population of Colorado beetles resistant to permethrin]. Biokhimiia. 1988 Jan;53(1):11-7. It was demonstrated that the activity of the main enzymes of insect detoxication, i.e., microsomal monooxygenases, nonspecific esterases and glutathione-S-transferases in the permetrin-resistant population of L-decemlineata is enhanced as compared with the permetrin-sensitive population. It was demonstrated that the inhibitors of microsomal monooxygenases, piperonyl butoxide, and of nonspecific esterases, butifos, significantly increase the sensitivity of the resistant population to permetrin. |
1(0,0,0,1) | Details |