| Name | Microsomal monooxygenase |
|---|---|
| Synonyms | ARO; Microsomal monooxygenase; Flavoprotein linked monooxygenase; ARO 1; ARO1; Aromatase; Aromatase cytochrome P450; CPV 1… |
| Name | piperonyl butoxide |
|---|---|
| CAS | 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9414486 | Feldwick MG, Noakes PS, Prause U, Mead RJ, Kostyniak PJ: The biochemical toxicology of 1,3-difluoro- the major ingredient of the pesticide gliftor: the potential of 4-methylpyrazole as an antidote. J Biochem Mol Toxicol. 1998;12(1):41-52. The conversion of 1,3-difluoro- to 1,3-difluoroacetone was found to be catalyzed by an (+)-dependent alcohol dehydrogenase, while the defluorination was attributed to microsomal monooxygenase activity induced by phenobarbitone and inhibited by piperonyl butoxide. 4-Methylpyrazole was found to inhibit both of these processes in vitro and when administered (90 mg kg-1 body weight) to rats, 2 hours prior to 1,3-difluoro- eliminated signs of poisoning, prevented (-) erythrofluorocitrate synthesis, and markedly decreased and accumulation in vivo. 4-Methylpyrazole also appeared to diminish (-) erythrofluorocitrate synthesis from fluoroacetate in vivo, and this was attributed to its capacity to inhibit malate dehydrogenase activity. |
81(1,1,1,1) | Details |
| 1473796 | Tada Y, Fujitani T, Yoneyama M: Acute renal toxicity of thiabendazole (TBZ) in ICR mice. Food Chem Toxicol. 1992 Dec;30(12):1021-30. TBZ-induced renal injury was reduced by pretreatment with inducers of the microsomal monooxygenase system phenobarbital, beta-naphthoflavone and 3-methylcholanthrene) and were enhanced by pretreatment with inhibitors of that system (2-diethylaminoethyl-2,2-diphenylvalerate hydrochloride and piperonyl butoxide). |
32(0,1,1,2) | Details |
| 6479106 | Ater SB, Swinyard EA, Tolman KG, Franklin MR: Anticonvulsant activity and neurotoxicity of piperonyl butoxide in mice. Epilepsia. 1984 Oct;25(5):551-5. Piperonyl butoxide, a microsomal monooxygenase inhibitor, administered intraperitoneally to mice exerts peak anti-maximal electroshock activity and peak neurotoxicity at 5 and 7h, respectively. |
31(0,1,1,1) | Details |
| 1856614 | Shukla A, Radin NS: Metabolism of D-[3H] threo-1-phenyl-2-decanoylamino-3-morpholino- an inhibitor of synthesis, and the synergistic action of an inhibitor of microsomal monooxygenase. J Lipid Res. 1991 Apr;32(4):713-22. This conclusion was confirmed by showing that the tissue levels of PDMP could be greatly elevated, for a much longer time, when the mice were pretreated with piperonyl butoxide or cimetidine. |
1(0,0,0,1) | Details |
| 7062265 | Kuo CH, Rush GF, Hook JB: Renal cortical accumulation of phenobarbital in rats and rabbits: lack of correlation with induction of renal microsomal monooxygenases. J Pharmacol Exp Ther. 1982 Mar;220(3):547-51. Renal cortical accumulation of phenobarbital in rats was also inhibited by piperonyl butoxide. |
0(0,0,0,0) | Details |