Protein Information

Name monoamine oxidase
Synonyms Adrenalin oxidase; Amine oxidase; Amine oxidase [flavin containing] B; MAO B; MAOB; Monoamine oxidase; Monoamine oxidase B; Monoamine oxidase type B…

Compound Information

Name piperonyl butoxide
CAS 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
7861152 Sriram K, Pai KS, Ravindranath V: Protection and potentiation of 1-methyl-4-phenylpyridinium-induced toxicity by cytochrome P450 inhibitors and inducer may be due to the altered uptake of the toxin. J Neurochem. 1995 Mar;64(3):1203-8.

MPP (+)-induced toxicity was abolished by pretreatment of the slices with inhibitors of monoamine oxidase (MAO; pargyline and deprenyl) or inhibitors of P450 (piperonyl butoxide or SKF-525A) or dopamine uptake blocker (GBR-12909), as measured by the activity of NADH-DH in slices and leakage of lactate dehydrogenase from the slice into the medium.
81(1,1,1,1) Details
1933335 Pai KS, Ravindranath V: Protection and potentiation of MPTP-induced toxicity by cytochrome P-450 inhibitors and inducer: in vitro studies with brain slices. Brain Res. 1991 Aug 2;555(2):239-44.

Other cytochrome P-450 inhibitors, namely, piperonyl butoxide and SKF 525A were found to offer protection against MPTP induced neurotoxicity in slices without affecting monoamine oxidase activity.
32(0,1,1,2) Details
1175733 Holden JS, Hadfield JR: Chlorodimeform and its effect on monoamine oxidase activity in the cattle tick, Boophilus microplus. Experientia. 1975 Sep 15;31(9):1015-7.

2(0,0,0,2) Details
7483660 Jenner AM, Timbrell JA: In vitro microsomal metabolism of hydrazine. Xenobiotica. 1995 Jun;25(6):599-609.


Microsomal enzyme inhibitors, piperonyl butoxide and metyrapone, significantly inhibited hydrazine metabolism but glutathione had no affect and was not depleted. 3.
0(0,0,0,0) Details