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Honscha W, Ottallah M, Schenk A, Schuh K, Petzinger E: Separation and purification by two-dimensional gel electrophoresis of a 52-54 kDa bumetanide binding protein from rat liver plasma membranes. Eur J Pharmacol. 1992 Jul 1;226(3):215-23.
The protein is assumed to represent the carrier for hepatic uptake of loop diuretics.
To detect possible binding of radioactive bumetanide to microsomal cytochrome P450s, photolabeling experiments with integral plasma membrane proteins were performed under nitrogen/carbon monoxide atmosphere and in the presence of piperonyl butoxide. |
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