| 6339097 |
Cottrell RC, Blowers SD, Walters DG, Lake BG, Purchase R, Phillips JC, Gangolli SD: Studies of the metabolic bioactivation of n-nitrosopyrrolidine in the rat. Carcinogenesis. 1983;4(3):311-4.
The metabolism of N-nitrosopyrrolidine (NPYR) to 4-hydroxybutanal (4-HB) (the first stable product of the putative alpha-hydroxylation pathway) and its bioactivation in the Ames bacterial mutagenicity test system were examined in the presence of a number of inhibitors.
Both SKF 525A and piperonyl butoxide were found to be potent inhibitors of the production of 4-HB by rat liver microsomal preparations but were ineffective in the mutagenicity model with liver S-9 from either untreated or Aroclor 1254 pretreated rats. |
2(0,0,0,2) |
Details |