| Name | Lipoxygenase (protein family or complex) |
|---|---|
| Synonyms | arachidonate lipoxygenase; arachidonate lipoxygenases; lipoxygenase; lipoxygenases |
| Name | piperonyl butoxide |
|---|---|
| CAS | 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2983324 | Luini AG, Axelrod J: Inhibitors of the cytochrome P-450 enzymes block the secretagogue-induced release of corticotropin in mouse pituitary tumor cells. Proc Natl Acad Sci U S A. 1985 Feb;82(4):1012-4. The stimulation of ACTH secretion induced by the secretagogues can be blocked by inhibitors of the enzymes that generate (phospholipase A2) and metabolize (lipoxygenase and epoxygenase) Blockers of the cytochrome P-450 epoxygenase, such as SKF 525A and piperonyl butoxide, compounds that have different molecular structures, also suppressed secretagogue-induced ACTH release. |
2(0,0,0,2) | Details |
| 3100285 | Marcocci C, Luini A, Santisteban P, Grollman EF: and thyrotropin stimulation of iodide efflux in FRTL-5 thyroid cells involves metabolites of and is associated with the iodination of thyroglobulin. Endocrinology. 1987 Mar;120(3):1127-33. Inhibitors of arachidonic acid metabolism via the lipoxygenase pathway, 5,8,11,14-eicosatetraynoic acid and nordihydroguaiaretic acid, and via the cytochrome P450-linked epoxygenase pathway, piperonyl butoxide and 2-diethylaminoethyl-2,2-diphenyl but not an inhibitor of the cyclooxygenase pathway, indomethacin, can inhibit TSH-, NE-, and A23187-induced I- efflux. The data thus suggest that TSH- and NE-induced I- efflux from FRTL-5 thyroid cells involves lipoxygenase and/or epoxygenase metabolites of released from phospholipids upon Ca2+-dependent activation of phospholipase A2. |
1(0,0,0,1) | Details |
| 8799885 | Gosling M, Poyner DR, Smith JW: Effects of upon the volume-sensitive current in rat osteoblast-like (ROS 17/2.8) cells. J Physiol. 1996 Jun 15;493 ( Pt 3):613-23. was still effective in the presence of inhibitors of cyclo-oxygenase (indomethacin, 10 microM), lipoxygenase (nordihydroguaretic acid, 10-100 microM) and cytochrome P450 (SKF525A, 100 microM; ethoxyresorufin, 10 microM; 500 microM; piperonyl butoxide, 500 microM; cimetidine, 1 mM). |
31(0,1,1,1) | Details |
| 8967773 | Masaphy S, Henis Y, Levanon D: -enhanced biotransformation of atrazine by the white rot fungus Pleurotus pulmonarius and its correlation with oxidation activity. Appl Environ Microbiol. 1996 Oct;62(10):3587-93. Antioxidants, mainly nordihydroguaiaretic acid, which inhibits lipoxygenase, peroxidase, and P-450 activities, and piperonyl butoxide, which inhibits P-450 activity, inhibited atrazine transformation by the mycelium. |
31(0,1,1,1) | Details |