| 15183889 |
Lester CH, Frimodt-Moller N, Hammerum AM: Conjugal transfer of aminoglycoside and macrolide resistance between Enterococcus faecium isolates in the intestine of streptomycin-treated mice. FEMS Microbiol Lett. 2004 Jun 15;235(2):385-91.
The purpose was to study conjugal transfer of resistance genes between a multi-resistant Enterococcus faecium isolate and a sensitive E. faecium isolate. Co-transfer of erm (B)-Tn5405-like element and aac (6')-Ie-aph (2'')-Ia was obtained in both in vivo and in vitro. Plasmid profiles and Southern blots showed that both the erm (B)-Tn5405-like element and aac (6')-Ie-aph (2'')-Ia were placed on the same large plasmid (> 147 kb). These data show to our knowledge the first co-transfer of the erm (B)-Tn5405-like element and aac (6')-Ie-aph (2'')-Ia. The in vivo study also indicates that transfer of resistance genes between enterococci might occur under natural conditions in the gut of animals. |
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