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Cho YJ, Moon DC, Jin JS, Choi CH, Lee YC, Lee JC: Genetic basis of resistance to aminoglycosides in Acinetobacter spp. and spread of armA in Acinetobacter baumannii sequence group 1 in Korean hospitals. Diagn Microbiol Infect Dis. 2009 Jun;64(2):185-90. Epub 2009 Apr 9.
A total of 75 Acinetobacter isolates resistant to all available aminoglycosides obtained from 2 Korean hospitals were studied for the genetic basis of resistance to aminoglycosides. The MIC (50) and MIC (90) of Acinetobacter baumannii isolates (n = 61) to amikacin, gentamicin, isepamycin spectinomycin, streptomycin, and tobramycin were higher than those of Acinetobacter genomic species 13TU isolates (n = 14). Genes encoding aminoglycoside-modifying enzymes, ant (3")-Ia, aac (6')-Ib, aph (3')-1a, aac (3)-Ia, and aph (3')-VI, and 16S ribosomal RNA (rRNA) methylase armA were detected. ant (3")-Ia and aac (6')-Ib were commonly detected in both Acinetobacter spp., but armA and aph (3")-Ia were only detected in A. baumannii. armA was located on the plasmids. A. baumannii isolates carrying armA were classified into 7 pulsotypes but belonged to sequence group 1. The combination of aminoglycoside-modifying enzymes is responsible for the moderate-level resistance to aminoglycosides in Acinetobacter genomic species 13TU, whereas armA is responsible for the high-level resistance to aminoglycosides in A. baumannii sequence group 1. |
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