| 21591746 |
Kannan R, Pillarsetty N, Gali H, Hoffman TJ, Barnes CL, Jurisson SS, Smith CJ, Volkert WA: Design and synthesis of a bombesin peptide-conjugated tripodal phosphino dithioether ligand topology for the stabilization of the fac-[M (CO) 3]+ core (M=(99 m) Tc or Re). Inorg Chem. 2011 Jul 4;50(13):6210-9. Epub 2011 May 18.
A new tumor-seeking tridentate topology consisting of a phosphino dithioether ((HOCH (2))(2) PCH (2) CH (2) S (CH (2))(n) CH (2) SR; PS (2)) ligand framework for the production of kinetically inert and in vivo stable facial [(99m) Tc (CO)(3)(PS (2))](+) or [Re (CO)(3)(PS (2))](+) is described. The X-ray crystal structure of fac-Re (CO)(3)(PS (2)) PF (6) is reported. The bioconjugation strategies for incorporating bombesin (BBN) peptides on to the PS (2) tripodal framework and, thereby, de novo designing of GRP receptor-seeking Tc (PS (2)-BBN)(CO)(3) are developed. |
32(0,1,1,2) |