| 18475995 |
Wisniewski MZ, Glowiak T, Opolski A, Wietrzyk J: Synthesis, Characterization and Antiproliferative Activity of the Co (II), Ni (II), Cu (II), Pd (II) and Pt (II) Complexes of 2-(4-Thiazolyl) Benzimidazole (Thiabendazole). Met Based Drugs. 2001;8(4):189-94.
Complexes of 2-(4-thiazolyi) benzimidazole (thiabendazole, THBD) with Co (II), Ni (II), Cu (ll) of general formula ML (2)(NO (3))(2) H (2) O and complexes of Pd (II) and Pt (II) of general formula ML2Cl (2) H (2) O have been obtained and characterized by elemental analyses, IR and far IR spectroscopy and magnetic measurements. The X-ray crystal structure of the copper (II) complex has been determined. The in vitro cell proliferation inhibitory activity of these compounds was examined against human cancer cell lines A 549 (lung carcinoma), HCV-29 T (urinary bladder carcinoma), MCF-7 (breast cancer), T47D (breast cancer), MES-SA (uterine carcinoma) and HL-60 (promyelocytic leukemia). Pt-THBD has been found to exhibit an antileukemic activity of the HL-60 line cells matching that of an arbitrary criterion. |
82(1,1,1,2) |