| 11498992 |
Zhou SS, Zang YM: [Effects of monocarboxylic acid derivatives on cardiac ventricular CFTR Cl- channels in guinea pig]. Sheng Li Xue Bao. 1999 Jun;51(3):297-302.
Using the whole-cell recording technique, the effects of monocarboxylic acid derivatives on cystic fibrosis transmembrane conductance regulator (CFTR) Cl (-)-channel were examined in guinea pig ventricular myocytes. Anthracene-9-carboxylic acid (9-AC) added to the bath solution further enhanced the outward component of isoproterenol-induced currents in a reversible manner, whereas 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) or diphenylamine-2-carboxylic acid (DPC) induced a biphasic effect on the currents. Either NPPB or DPC first produced a transient increase in the outward component of current before ensuing inhibition. Intracellular NPPB was found to potentiate isoproterenol-activated currents. It is concluded that these monocarboxylic acid derivatives have different binding sites in cardiac ventricular myocytes, which might partially account for the varied effects in blocking anion channels. |
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