| 9989472 |
Sahoo A, Samanta L, Das A, Patra SK, Chainy GB: Hexachlorocyclohexane-induced behavioural and neurochemical changes in rat. J Appl Toxicol. 1999 Jan-Feb;19(1):13-8.
Effect of chronic oral exposure (10 and 20 mg kg (-1) body wt. for 7, 15 and 30 days) to hexachlorocyclohexane (HCH) on open-field behaviour and activities of cerebral Na+,K+-ATPase, Mg2+-ATPase and acetylcholinesterase (AChE) of rat was evaluated. Motor and grooming activities were altered, whereas vertical exploratory activity was unaffected by HCH. Activities of Na+,K+-ATPase, Mg2+-ATPase and AChE were inhibited significantly by the pesticide. The results suggest that HCH induces impairment of the enzymes involved in synaptic activity, resulting in behavioural alterations. |
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